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20 October 2021 Volume 41 Issue 5
Study on Vascular Irritation and Active Systemic Anaphylaxis of
99mTc-GSA
Injection
Sun Ge, Zhang Wei, Huang Liqun, Xu Wenli, Gao Jie, Liu Huan, Qin Xiujun, Li Jianguo
RADIATION PROTECTION BULLETIN. 2021, 41(5): 2-5.
Abstract
(
93
)
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(599KB) (
114
)
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We evaluate the vascular irritation and active systemic allergy of the radiodiagnostic drug Technetium
99m
Tc-GSA injection,to provide reference for the clinical safety application of radiopharmaceutical drugs. The results show that there is no vascular irritation reaction after intravenous injection,and strong positive allergic reactions can be avoided by single clinical use.
Establishment of VX2 Rabbit Hepatocellular Carcinoma in Situ Model and Hepatic Artery Interventional Radioembolization Microsphere Method and Related Radiation Protection Issues
Wang Zhipeng, Yin Jingjing, Xu Wenli, Sun Fe, Gao Jie, Zhang Wei, Qin Xiujun, Li Jianguo, Liu Huan
RADIATION PROTECTION BULLETIN. 2021, 41(5): 6-9.
Abstract
(
75
)
PDF
(611KB) (
86
)
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Wehave exploredto establish an in situ model of rabbit VX2 hepatocellular carcinoma,and a method of hepatic artery interventional radioembolization microsphere,and further discuss key operational considerations involved. Also at the same time,we address some radiation protection issues associated with the process.
In Vitro Screening of Targeted Drugs Labelled by Isotopes
Huang Liqun, Li Shufang, Zhou Wenhua, Sun Ge, Qin Xiujun, Li Jianguo
RADIATION PROTECTION BULLETIN. 2021, 41(5): 10-13.
Abstract
(
88
)
PDF
(1341KB) (
195
)
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Based on the LNCaP cell-specific membrane antigen target for human prostate cancer,an equal amount of
125
I-labelled reference compound
125
I-A was added to the porous filter plate,and then different concentrations of ligands to be tested were added. With competitive binding assays,the affinity between drugs and targets wasstudied. We thus establish a screening method for targeted drugs based on isotope labelling invitro.
Radiation Monitoring and Protection for
99m
Tc in Animal Experiments of Radiopharmaceuticals
Xu Wenli, Li Jianhua, Huang Liqun, Zhang Wei, Liu Huan, Qin Xiujun, Li Jianguo
RADIATION PROTECTION BULLETIN. 2021, 41(5): 14-18.
Abstract
(
82
)
PDF
(778KB) (
112
)
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By analyzing the dose monitoring data of external exposure arising from animal experiments of radiopharmaceuticals with
99m
Tc,the occupational dose status of workers in different positions and the exposure effects among experimental animals were evaluated,so as to provide reference for further improving the optimization level of radiation protection.
Effects of Gamma Rays on Intestinal Tissue and Fecal Flora of Beagles
Xu Wenli, Li Shufang, Wang Xingang, Wang Yuanfei, Wang Yongli, Hu Bo, Li Jianguo
RADIATION PROTECTION BULLETIN. 2021, 41(5): 19-23.
Abstract
(
45
)
PDF
(1287KB) (
73
)
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Using 16srDNA technique,the dose effect of whole body exposure to
60
Coγ-rays on the intestinal tissue and faecal flora of Beagles was analysed. The results showed that different doses of
60
Co could change the structure of fecal microflora,and promote or aggravate intestinal damage,of Beagles.
Effects of Gamma Rays on Coagulation Function of Beagle
Li Shufang, Yue Juan, Xu Wenli, Huang Liqun, Wang Zhipeng, Sun Ge, Hu Bo
RADIATION PROTECTION BULLETIN. 2021, 41(5): 24-27.
Abstract
(
69
)
PDF
(608KB) (
87
)
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After systemic unilateral exposure to
60
Co with different doses,the changes of platelets and coagulation function in beagles were observed at different times. The results showed that both low and high dose could activate endogenous coagulation mechanism,thrombosis and fibrinolysis hyperactivity,and the mechanism of bleeding death induced by high dose was related to the disorder of blood coagulation,anticoagulation and fibrinolysis system.
Establishment of Radio-proctitis Model in SD Rats
Yuan Hui, Liu Mengya, Liu Huan, Li Jianguo
RADIATION PROTECTION BULLETIN. 2021, 41(5): 28-30.
Abstract
(
107
)
PDF
(597KB) (
223
)
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With high-dose X-rays given twice to SD rats locally in singlepass,we explore to establish a radio-proctitis model in rats,via observing the clinical symptoms and histopathological changes. It shows that acute radio-proctitis in rats can be induced successfully by a single local X-ray exposure of 18 Gy. Our model is suitable for the study of the therapeutic effect of radiorectal damage drugs.
Discussion on the Protective Effect of Oligochitosan on Radiation Damage in Mice
Guo Jianping, Zhang Huaping, Zhou Chaodong, Yang Zhongtian
RADIATION PROTECTION BULLETIN. 2021, 41(5): 31-35.
Abstract
(
54
)
PDF
(1493KB) (
88
)
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The protective effect of oligochitosan on radiation damage in mice exposed to gamma rays was explored by means of flow cytometry,RT-PCR,Western blotting. The changes in bone marrow nucleated cells,lymphocyte apoptosis,spleen organ coefficient,cell apoptosis-related genes,P53 protein and GADD45 protein were tested. As compared with the control group,γ-ray exposed mice with a gavage of oligochitosan showed an improved survival rate,increase numbers of bone marrow nucleated cells,reduced numbers of apoptotic cells in bone marrow lymphocytes. For the test group,oligochitosan was observed to be able to down-regulate Bax,caspas-3 and up-regulate Bc1-2 for apoptosis-related genes,which give rise to anincreased Bcl-2/Bax ratio,and inhibite expression of P53 protein and GADD45 protein also. It suggests that oligochitosan may inhibit the expression of P53 protein and GADD45 protein,affect the expression of apoptosis-related genes,inhibit the production of apoptotic cells,and promote haematopoietic function recovery,and thus protect mice from radiation damage.
Quality Assurance for Non-clinical Safety Evaluation of Radiopharmaceuticals
Yin Jingjing, Li Mei, Liu Xiaoming, Yuan Hui, Qin Xiujun, Li Jianguo
RADIATION PROTECTION BULLETIN. 2021, 41(5): 36-38.
Abstract
(
76
)
PDF
(590KB) (
126
)
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Wepresent our quality assurance procedures for non-clinical safety evaluation of radiopharmaceuticals from five aspects,including laboratory management,personnel management,subject management,key test-stage inspection,and on-site inspection,to ensure the authenticity and accuracy of test data and the safety of personnel and environment.
Effect of Single-pass Linear Accelerator Radiation on Metablism of Capecitabine in vivo
Wang Ruoqi, Li Jianhua, Wang Zhipeng, Liu Huan, Zhang Guoliang, Gao jie
RADIATION PROTECTION BULLETIN. 2021, 41(5): 39-43.
Abstract
(
59
)
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(1066KB) (
234
)
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The concentration of capecitabine and 5-fluorouracil in blood and the concentration of capecitabine in the intestinal single-pass perfusion effluent were tested by UPLC-MS/MS after single exposure of SD rats by linear accelerator.
C
max
,
T
max
,
t
1/2
,
AUC
,absorption rate constant (
K
a
) and apparent absorption coefficient(
P
app
) were then calculated. It showes that the testing method is simple and reproducible,and can simultaneously determine the prototype drug capecitabine and active metabolite 5-fluorouracil in rat plasma. Our analysis indicate that the single exposure of 10 Gy in the abdomen of linear accelerator has inhibited the absorption of capecitabine into the blood circulation in the small intestine and colon,resulting in delayed peak reaching time,decreased peak concentration and blood drug concentration,and accelerated excretion,while capecitabine metabolic rate hasn’tbeen affected.
Overview of Industry Guidelines for Radiopharmaceutical Preclinical Study
Gao Jie, Zhou Wenhua, Liu Xiaoming, Liu Huan, Wang Ruoqi, Yin Jinjin, Li Jiangguo
RADIATION PROTECTION BULLETIN. 2021, 41(5): 44-47.
Abstract
(
265
)
PDF
(617KB) (
658
)
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We introduce radiopharmaceutical regulatory management systems in the United States,Europe and China,describe the process of applying for clinical study of radiopharmaceuticals in China,and compare the legal and regulatory differences and similarities in China with Europe and America in the respect.
Discussion on the Research Direction of Hypothermia Therapy for Radiation Damage Based on Arrowsmith
LiuHuan, Liu Xiaoming, Xu Wenli, Yuan Hui, Qin Xiujun, li Shufang, Li Jianguo
RADIATION PROTECTION BULLETIN. 2021, 41(5): 48-52.
Abstract
(
68
)
PDF
(631KB) (
323
)
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Arrowsmith tool was used to explore the potential association between hypothermia therapy and radiation damage by taking PubMed literature as the analysis object. The results showed that there are about 30 keywords with extremely high correlation,and the top 5 are akt,pi3k,trpv1,toll receptor,Caspase-3 gene targets.
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