RADIATION PROTECTION BULLETIN ›› 2021, Vol. 41 ›› Issue (5): 28-30.

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Establishment of Radio-proctitis Model in SD Rats

Yuan Hui, Liu Mengya, Liu Huan, Li Jianguo   

  1. GLP Center,China Institute for Radiation Protecton,Taiyuan,Shanxi 030006
  • Received:2021-08-26 Online:2021-10-20 Published:2022-03-31

Abstract: With high-dose X-rays given twice to SD rats locally in singlepass,we explore to establish a radio-proctitis model in rats,via observing the clinical symptoms and histopathological changes. It shows that acute radio-proctitis in rats can be induced successfully by a single local X-ray exposure of 18 Gy. Our model is suitable for the study of the therapeutic effect of radiorectal damage drugs.

Key words: Radio-proctitis, Rats, X-ray

CLC Number: 

  • R818