低聚壳聚糖对小鼠的辐射损伤防护作用探讨

Abstract

Abstract: The protective effect of oligochitosan on radiation damage in mice exposed to gamma rays was explored by means of flow cytometry,RT-PCR,Western blotting. The changes in bone marrow nucleated cells,lymphocyte apoptosis,spleen organ coefficient,cell apoptosis-related genes,P53 protein and GADD45 protein were tested. As compared with the control group,γ-ray exposed mice with a gavage of oligochitosan showed an improved survival rate,increase numbers of bone marrow nucleated cells,reduced numbers of apoptotic cells in bone marrow lymphocytes. For the test group,oligochitosan was observed to be able to down-regulate Bax,caspas-3 and up-regulate Bc1-2 for apoptosis-related genes,which give rise to anincreased Bcl-2/Bax ratio,and inhibite expression of P53 protein and GADD45 protein also. It suggests that oligochitosan may inhibit the expression of P53 protein and GADD45 protein,affect the expression of apoptosis-related genes,inhibit the production of apoptotic cells,and promote haematopoietic function recovery,and thus protect mice from radiation damage.

Key words: Oligochitosan, Radiation protection, Mice

CLC Number:

R818

Guo Jianping, Zhang Huaping, Zhou Chaodong, Yang Zhongtian. Discussion on the Protective Effect of Oligochitosan on Radiation Damage in Mice[J].RADIATION PROTECTION BULLETIN, 2021, 41(5): 31-35.

[1]	Wang Zhipeng, Yin Jingjing, Xu Wenli, Sun Fe, Gao Jie, Zhang Wei, Qin Xiujun, Li Jianguo, Liu Huan. Establishment of VX2 Rabbit Hepatocellular Carcinoma in Situ Model and Hepatic Artery Interventional Radioembolization Microsphere Method and Related Radiation Protection Issues [J]. RADIATION PROTECTION BULLETIN, 2021, 41(5): 6-9.
[2]	Wang Chuangao, Chen Qianlan, Xia Yihua, Wang Wei, Pang Hongchao, Luo Zhiping, Chen Ling. Dose Coefficients for Occupational Internal Dose Assessment Provided in Latest ICRP Series Reports [J]. RADIATION PROTECTION BULLETIN, 2021, 41(2): 1-10.
[3]	Cao Jiayi, Wang Wenwen. Radiation Protection Design and Verification of a Nuclear Technology Utilization Project in Hunan [J]. RADIATION PROTECTION BULLETIN, 2021, 41(2): 23-28.
[4]	HU Fengyuan, LU Xiaoxiao, MU Xuechen, LI Peng, XIN Xueya, LI Wanqing, DUAN Yunyan. Investigation on Radiation Protection of Medical Staff in Radiology Department of Medical Institution in Xi'an [J]. RADIATION PROTECTION BULLETIN, 2021, 41(1): 22-29.
[5]	Shufeng, Wang Li, Yu Fengqi, Yin Aimin, Ma Dexun. Analysis on Capacity Building of Protection and Medical Rescue for Nuclear Emergency in Grass-roots Units [J]. RADIATION PROTECTION BULLETIN, 2020, 40(1): 23-26.
[6]	Zhang Cheng, Zhang Ling, Yin Chunxu, He Tinggui, He Lijuan. Key Points in Construction and Acceptance Monitoring for DR Machine Rooms [J]. RADIATION PROTECTION BULLETIN, 2020, 40(1): 17-22.
[7]	Bian Huahui, Wang Min, Sun Liang, Chen Weibo, Wang Youyou, Zhang Yusong, Wei Jing, Dai Hong, Feng Junchao, Liu Yulong. Medical Evaluation and Consideration forSeven Radiation Workers Suspected of Overexposure [J]. RADIATION PROTECTION BULLETIN, 2020, 40(1): 1-5.
[8]	Gao Hongbo, Bai Jing, Li Longmin, Liu Haichun, Zhang Xiaoyong, Shao Yujun, Pang hua. Radiation Protection for Differentiated Thyroid Cancer Patients with ¹³¹I Therapy [J]. RADIATION PROTECTION BULLETIN, 2019, 39(6): 14-18.
[9]	Zhou Tienan, Xie Wenjin, Xu Minghua, Gong Lei, Dai Shengqian, Wang Li. Personal Dose Monitoring of a Nuclear Power Plant in 2018 [J]. RADIATION PROTECTION BULLETIN, 2019, 39(4): 33-36.
[10]	Liu Zhongshu, Li Hong, He Liangguo, Wen Xiangmin. Radiation Level of a PWR Nuclear Fuel Element Production Line and Its Health Impacts on Operators [J]. RADIATION PROTECTION BULLETIN, 2019, 39(4): 27-32.
[11]	Zhuang Shuqi, Liu Yulong. Riskand Protection of Oral X-ray Examinations in Pregnant Women [J]. RADIATION PROTECTION BULLETIN, 2019, 39(3): 44-48.
[12]	Yang Jun, Lv Yvming, Dong Shengnan. Radiation Protection Design of a Halcyon Self-shielding Medical Linear Accelerator Facility [J]. RADIATION PROTECTION BULLETIN, 2019, 39(3): 22-25.
[13]	Yang Junwu, Yu Enjian, Wang Chuan, Lun Zhenming, Wu Huiyuan. Alpha Radiation Measurement and Protection in PWR Nuclear Power Plants [J]. RADIATION PROTECTION BULLETIN, 2019, 39(3): 10-15.
[14]	Qiu Xinyu, Yan Yujie, Xi Kedi, Zhang Kunlan, Hu Wentao, Zhang Jian. Research Progress on Radiation-induced Bone Loss and its Protection [J]. RADIATION PROTECTION BULLETIN, 2019, 39(2): 23-33.
[15]	Wang Jiping, Yang Zhiyong, Yuan Hong, Chen Chuanxi. The Continuous Improvement And Analysis of Radiation Protection Management Based on PDCA Cycle in the Radiotherapy Department [J]. RADIATION PROTECTION BULLETIN, 2018, 38(3): 24-28.

Discussion on the Protective Effect of Oligochitosan on Radiation Damage in Mice

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10