活性氧与放射性皮肤损伤的研究进展

摘要/Abstract

摘要： 机体受到意外照射或在接受放射治疗时会引起放射性皮肤损伤,皮肤组织中最先发生水分解而产生活性氧,其次呼吸链及炎症过程也会产生大量活性氧。活性氧作为信号分子在调控生理生化过程中起到了不可替代的作用。本文就辐射刺激后皮肤内活性氧变化、活性氧干预放射性皮肤损伤的机制以及活性氧消除调控放射性损伤等三个方面的研究进展进行综述,旨在联系活性氧代谢与放射性损伤的生理病理反应,为相关研究及临床治疗提供便利。

关键词: 放射性皮肤损伤, 活性氧, 自噬, 凋亡, 炎症

Abstract: When the skin is irradiated by radioactive sources, the decomposition of water is the first process to produce reactive oxygen species (ROS), and then the respiratory chain and inflammatory process also produce a large number of ROS. As a signal molecule, ROS plays an irreplaceable role in regulating physiological and biochemical processes. In this paper, the changes of ROS by radiation-induced skin injury, the mechanism of ROS intervention and the regulation of ROS elimination were reviewed in order to link the metabolism of ROS with the physiological and pathological reaction of radiation injury, so as to provide reference for related research and clinical treatment.

Key words: radiation-induced skin injury, reactive oxygen species, autophagy, apoptosis, inflammation

中图分类号:

R818.7

蔡卫超, 曹卫红. 活性氧与放射性皮肤损伤的研究进展[J]. 辐射防护, 2022, 42(2): 111-118.

CAI Weichao, CAO Weihong. Research progress of reactive oxygen species and radiation-induced skin injury[J]. RADIATION PROTECTION, 2022, 42(2): 111-118.

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