微波辐射对家兔血清心肌酶活性及心脏血流动力学的影响

辐射防护 ›› 2016, Vol. 36 ›› Issue (6): 387-392.

微波辐射对家兔血清心肌酶活性及心脏血流动力学的影响

李妍, 沈楠, 朱文赫, 钟秀宏, 侯建成, 吕士杰

吉林医药学院,吉林省吉林市 132013

收稿日期:2015-05-22 出版日期:2016-11-20 发布日期:2021-11-15
通讯作者: 吕士杰。E-mail:lvshjie-qr@163.com
作者简介:李妍(1974—),女,2010年毕业于中国医科大学细胞生物学专业,获博士学位,副教授。E-mail:liyan511700@163.com
基金资助:
国家自然科学基金资助项目(No:81301450);吉林省卫生厅科技计划项目(No:2012Z066)。

Effects of microwave radiation on serum myocardial enzyme activity and hemodynamics in rabbit

Li Yan, Shen Nan, Zhu Wenhe, Zhong Xiuhong, Hou Jiancheng, Lv Shijie

Jilin Medical College, Jilin 132013

Received:2015-05-22 Online:2016-11-20 Published:2021-11-15

摘要/Abstract

摘要： 采用平均功率密度为100 mW/cm²和200 mW/cm²的微波照射新西兰家兔20 min,探讨微波辐射对家兔心肌酶活性及心脏血流动力学影响及其意义。结果表明,微波照射5 min后,家兔呼吸(R)、心率(HR)加快。100 mW/cm²照射10～15 min后,家兔血压(BP)和左心室收缩压(LVSP)升高,左心室内压最大上升速率(+dp/dtm)和左心室内压最大下降速率(-dp/dtm)增加,左心室舒张压(LVDP)和左心室终末舒张压(LVEDP)下降,等容舒张时间室内压下降的时间常数(T)值减小;心电图(ECG)R波、QR波异常,偶发全身抽搐。200 mW/cm²照射5 min后,ECG异常以R波、QR波畸形较多,有锯齿形波,出现多次全身抽搐;照射15～20 min时,LVDP明显下降,T值减小,+dp/dtm和-dp/dtm明显增加。照射停止后,各组家兔R、HR立刻减慢,BP下降。停止照射6 h时,R、HR继续减慢,BP不断下降,LVSP逐渐降低,+dp/dtm和-dp/dtm减少,LVDP和LVEDP逐渐升高,T值增大。照射后各组家兔血清心肌酶活性明显升高。实验证明高功率微波辐射对家兔心脏结构和舒缩功能有明显影响,且损伤作用与照射强度密切相关。

关键词: 微波, 家兔, 心肌酶, 心脏血流动力学

Abstract: Microwaves with a mean power density of 100 mW/cm² and 200 mW/cm² (HPM) were adopted to investigate the effects of microwave radiation on serum myocardial enzyme activity and hemodynamics in rabbits. Observations show that R and HR speed up after microwave irradiation for 5 min. BP and LVSP increased, +dp/dtm and -dp/dtm increased, LVDP and LVEDP decreased, T value decreased abnormal electrocardiogram (ECG) waveform appear convulsions during 10—15 min in 100 mW/cm² irradiation. ECG wave abnormalities, repeated convulsions irradiated by 200 mW/cm² at 5 min. LVDP decreased significantly, T decreased, +dp/dtm and -dp/dtm increased significantly at 15—20 min after microwave irradiation. After irradiation, all rabbits hemodynamics changes immediately. R, HR decreased, BP decreased, LVSP decreased gradually, +dp/dtm and -dp/dtm were significantly decreased, LVDP and LVEDP increased, the T value increases after microwave irradiation of 6 h for dynamic observation. The serum myocardial enzymes were significantly increased after irradiation. These results demonstrate that high power microwave radiation has a significant effect on rabbit cardiac function, and the effect of injury is closely related to radiation intensity.

Key words: microwave, rabbit, myocardial enzyme, cardiac hemodynamics

中图分类号:

R363.1

李妍, 沈楠, 朱文赫, 钟秀宏, 侯建成, 吕士杰. 微波辐射对家兔血清心肌酶活性及心脏血流动力学的影响[J]. 辐射防护, 2016, 36(6): 387-392.

Li Yan, Shen Nan, Zhu Wenhe, Zhong Xiuhong, Hou Jiancheng, Lv Shijie. Effects of microwave radiation on serum myocardial enzyme activity and hemodynamics in rabbit[J]. RADIATION PROTECTION, 2016, 36(6): 387-392.

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