指甲电子顺磁共振(EPR)波谱解析的数学模拟研究

辐射防护 ›› 2021, Vol. 41 ›› Issue (3): 210-217.

指甲电子顺磁共振(EPR)波谱解析的数学模拟研究

阎长鑫, 刘玉连, 焦玲, 张文艺

中国医学科学院北京协和医学院放射医学研究所,天津 300192

收稿日期:2020-11-04 出版日期:2021-05-20 发布日期:2021-07-12
通讯作者: 张文艺。E-mail:wzhang.irm@163.com
作者简介:阎长鑫(1993—),男,2016年毕业于天津医科大学生物医学工程专业,现为北京协和医学院放射医学研究所硕士研究生。E-mail:645585929@qq.com
基金资助:
中国医学科学院医学与健康科技创新工程重大项目(2017-I2M-1-016)。

Study on mathematical simulation of electron paramagnetic resonance (EPR) spectrum analysis of nail

YAN Changxin, LIU Yulian, JIAO Ling, ZHANG Wenyi

Institute of Radiation Medicine, Chinese Academy of Medical Science, Peking Union Medical College, Tianjin 300192

Received:2020-11-04 Online:2021-05-20 Published:2021-07-12

摘要/Abstract

摘要： 探究数学拟合指甲电子顺磁共振(EPR)谱的方法,将相互重叠的信号剥离为较纯净的辐射诱发信号(RIS),在一定程度上减小本底信号对剂量重建的影响。利用C++编写代码,Visual Studio 2019社区版作为集成开发环境(IDE),在Windows10平台下,对EPR图谱进行有效信息提取、模拟、拟合、归一化,剂量回归。结果表明:对于指甲作为生物材料进行的剂量估算,个人的3组数学模拟,其残谱都接近于一条直线,剂量回归曲线R²大于0.9,拟合误差小于1 Gy(RIS2+RIS5,1~10 Gy照射范围)。对于10人混合组,R²接近0.9(0.89),拟合误差在1.1 Gy左右(RIS2+RIS5,1~10 Gy照射范围);10人混合组(RIS5)R²大于0.9,拟合误差4.78 Gy(5~55 Gy照射范围)。(RIS2+RIS5)实验组相对拟合误差总体优于谱减法;10人混合组(RIS5)拟合效果较差。

关键词: 指甲, EPR, 剂量估算, 波谱解析

Abstract: The objective of this study is to explore the decomposition method of electron paramagnetic resonance (EPR) spectra of fingernails after water treatment, and complete dose estimation using nails as biomaterials. Using C++ to write code, visual studio 2019 Community Edition as the integrated development environment (IDE), under the platform of windows10, the effective information extraction, fitting, simulation, normalization, dose regression of electron paramagnetic resonance spectroscopy were carried out. The results showed that the residual spectra of the three groups of individual samples(RIS2+RIS5,1-10 Gy exposure)are close to a straight line, the R² of dose regression curve is greater than 0.9, and the fitting error is less than 1 Gy. For the 10 person mixed group(RIS2+RIS5,1-10 Gy exposure), R² was close to 0.9 (0.89), and the fitting error was about 1.1 Gy, while for the RIS5 fitting group, R² was greater than 0.9, and the fitting error was 4.78 Gy (5-55 Gy exposure). By fitting the EPR spectrum of fingernails with mathematical simulation, we can separate the overlapped signals into RIS spectrum, which can reduce the influence of background signal on dose reconstruction to a certain extent.

Key words: nail, EPR, dose estimation, spectrum analysis

中图分类号:

TB98

阎长鑫, 刘玉连, 焦玲, 张文艺. 指甲电子顺磁共振(EPR)波谱解析的数学模拟研究[J]. 辐射防护, 2021, 41(3): 210-217.

YAN Changxin, LIU Yulian, JIAO Ling, ZHANG Wenyi. Study on mathematical simulation of electron paramagnetic resonance (EPR) spectrum analysis of nail[J]. RADIATION PROTECTION, 2021, 41(3): 210-217.

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