DNA甲基化在钚辐射损伤机制中的研究进展

摘要/Abstract

摘要： 常规辐射流行病学在评价低剂量辐射生物效应方面存在一定的局限性,利用分子生物学方法研究辐射人群远后健康效应是目前辐射流行病学研究的主要趋势。本文对DNA甲基化、生物学意义、应用及其与电离辐射的关系进行综述,介绍了其在钚辐射损伤中的机制。从DNA甲基化方面对辐射致癌流行病学进展进行研究,为我国钚接触人群的流行病学研究提供思路和借鉴。

关键词: DNA甲基化, 辐射致癌, 钚接触人群

Abstract: Conventional radiation epidemiology has some limitations in evaluating the biological effects of low dose radiation. It is the main trend of radiation epidemiology to study the late health effects of radiation exposured population by molecular biological methods. The DNA methylation, its biological significance and applications, as well as its relationship with ionizing radiation are reviewed in this paper. The mechanism of DNA methylation in plutonium radiation damage is introduced. The epidemiology study of radiation carcinogenesis starts from the aspect of DNA methylation, will provide good references for the epidemiological study of workers exposed to plutonium in China.

Key words: DNA methylation, radiation carcinogenesis, workers exposed to plutonium

中图分类号:

Q691

刘晓明, 古晓娜, 苏丽霞, 张艳娜. DNA甲基化在钚辐射损伤机制中的研究进展[J]. 辐射防护, 2023, 43(2): 122-127.

LIU Xiaoming, GU Xiaona, SU Lixia, ZHANG Yanna. Research progress of DNA methylation in plutonium radiation damage mechanisms[J]. RADIATION PROTECTION, 2023, 43(2): 122-127.

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