高压氧治疗在乳腺癌放射性皮炎中的作用

doi:10.27045/j.1000-8187.202603009

辐射防护 ›› 2026, Vol. 46 ›› Issue (3): 265-271.doi: 10.27045/j.1000-8187.202603009

高压氧治疗在乳腺癌放射性皮炎中的作用

崔玲¹, 田龙¹, 时秀菊², 王乐¹, 牛萍¹

1.河北北方学院附属第一医院放疗科,河北张家口 075000;
2.唐山市人民医院放疗中心,河北唐山 063000

收稿日期:2025-11-27 出版日期:2026-05-20 发布日期:2026-06-18
通讯作者: 石秀菊。E-mail:1277473912@qq.com
作者简介:崔玲(1984—),女,2012年毕业于北京中医药大学护理专业,中级主管职称。E-mail:zjkxhtl@126.com
基金资助:
中文基金项目张家口市科技计划项目(2522119D)。

Study on the effect of hyperbaric oxygen therapy for radiation dermatitis in breast cancer

CUI Ling¹, TIAN Long¹, SHI Xiuju², WANG Le¹, NIU Ping¹

1. Department of Radiotherapy, the First Affiliated Hospital of Hebei North University, Hebei Zhangjiakou 075000;
2. Radiotherapy Center of Tangshan People′s Hospital, Hebei Tangshan 063000

Received:2025-11-27 Online:2026-05-20 Published:2026-06-18

摘要/Abstract

摘要： 为了评价高压氧治疗对乳腺癌图像引导放疗所致皮炎的治疗效果,收集了河北北方学院附属第一医院2023年11月至2025年4月期间治疗的乳腺癌放射性皮炎患者,随机分为试验组与对照组,对照组执行一般干预措施,试验组在其基础上增加高压氧治疗,于治疗第1~12周比较两组放射性皮炎级别、皮肤病生活质量指数及不良反应发生率,经统计学分析,第8~10周对照组级别和指数均高于试验组(P＜0.05),两组不良事件发生率无差异(P＞0.05),说明高压氧治疗降低了乳腺癌IGRT引发的放射性皮炎级别和皮肤病生活质量指数,具有一定的临床应用价值。

关键词: 乳腺肿瘤, 图像引导放疗, 高压氧, 皮炎

Abstract: To evaluate the therapeutic effect of hyperbaric oxygen therapy on radiodermatitis induced by image-guided radiotherapy (IGRT) for breast cancer. The patients with radiodermatitis from breast cancer treated in the First Affiliated Hospital of Hebei North University from November 2023 to April 2025 were enrolled. After undergoing modified radical mastectomy, the patients underwent IGRT calibrated with cone-beam CT and were randomly divided into the test group and the control group. The control group received conventional interventions, while the test group received additional hyperbaric oxygen therapy. the level of radiodermatitis, dermatology life quality index, and incidence of adverse events were compared between the two groups from Week 1 to Week 12. Statistical analysis showed that both the levels and dermatology life quality index were higher in the control group than those in the test group from Week 8 to Week 10 (P<0.05), while there was no difference in the incidence of adverse events between the two groups (P>0.05). Hyperbaric oxygen therapy reduced the levels of radiodermatitis and dermatology life quality index caused by IGRT for breast cancer, demonstrating its clinical value.

Key words: breast neoplasms, image-guided radiotherapy, hyperbaric oxygen, radiodermatitis

中图分类号:

R473.73

崔玲, 田龙, 时秀菊, 王乐, 牛萍. 高压氧治疗在乳腺癌放射性皮炎中的作用[J]. 辐射防护, 2026, 46(3): 265-271.

CUI Ling, TIAN Long, SHI Xiuju, WANG Le, NIU Ping. Study on the effect of hyperbaric oxygen therapy for radiation dermatitis in breast cancer[J]. RADIATION PROTECTION, 2026, 46(3): 265-271.

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高压氧治疗在乳腺癌放射性皮炎中的作用

Study on the effect of hyperbaric oxygen therapy for radiation dermatitis in breast cancer

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