RADIATION PROTECTION ›› 2023, Vol. 43 ›› Issue (2): 122-127.

Previous Articles     Next Articles

Research progress of DNA methylation in plutonium radiation damage mechanisms

LIU Xiaoming, GU Xiaona, SU Lixia, ZHANG Yanna   

  1. China Institute for Radiation Protection, Taiyuan 030006
  • Received:2022-07-12 Online:2023-03-20 Published:2023-05-11

Abstract: Conventional radiation epidemiology has some limitations in evaluating the biological effects of low dose radiation. It is the main trend of radiation epidemiology to study the late health effects of radiation exposured population by molecular biological methods. The DNA methylation, its biological significance and applications, as well as its relationship with ionizing radiation are reviewed in this paper. The mechanism of DNA methylation in plutonium radiation damage is introduced. The epidemiology study of radiation carcinogenesis starts from the aspect of DNA methylation, will provide good references for the epidemiological study of workers exposed to plutonium in China.

Key words: DNA methylation, radiation carcinogenesis, workers exposed to plutonium

CLC Number: 

  • Q691