DNA甲基化在钚辐射损伤机制中的研究进展

Abstract

Abstract: Conventional radiation epidemiology has some limitations in evaluating the biological effects of low dose radiation. It is the main trend of radiation epidemiology to study the late health effects of radiation exposured population by molecular biological methods. The DNA methylation, its biological significance and applications, as well as its relationship with ionizing radiation are reviewed in this paper. The mechanism of DNA methylation in plutonium radiation damage is introduced. The epidemiology study of radiation carcinogenesis starts from the aspect of DNA methylation, will provide good references for the epidemiological study of workers exposed to plutonium in China.

Key words: DNA methylation, radiation carcinogenesis, workers exposed to plutonium

CLC Number:

Q691

LIU Xiaoming, GU Xiaona, SU Lixia, ZHANG Yanna. Research progress of DNA methylation in plutonium radiation damage mechanisms[J].RADIATION PROTECTION, 2023, 43(2): 122-127.

References

[1] Hada M, Georgakilas A G. Formation of clustered DNA damage after high-LET irradiation:A review[J]. J Radiat Res, 2008, 49 (3):203-210.
[2] ICRP. The 2007 recommendations of the International Commission on Radiological Protection[R]. ICRP Publication 103. Annals of the ICRP, 2007(37).
[3] 刘晓冬, 焦本蒸,刘杉珊, 等. 低剂量辐射效应及辐射的表观遗传学调控[J]. 辐射防护通讯, 2009, 29(5):41-49.
LIU Xiaodong, JIAO Benzheng, LIU Shanshan, et al. Low dose radiation responses and epigenetics regulation[J]. Radiation Protection Bulletin, 2009, 29(5): 41-49.
[4] Jones P A. Functions of DNA methylation: islands, start sites, gene bodies and beyond[J]. Nat Rev Genet, 2012, 13(7): 484-492.
[5] Jones P A, Baylin S B. The fundamental role of epigenetic events in cancer [J]. Nat Rev Genet, 2002, 3(6): 415-428.
[6] Robertson K D. DNA methylation and human disease[J]. Nat Rev Genet, 2005, 6(8):597-610.
[7] Weber M, Hellmann I, Stadler M B, et al. Distribution, silencing potential and. evolutionary impact of promoter DNA methylation in the human genome[J]. Nature Genetics, 2007, 39(4):457-466.
[8] Strathdee G, Brown R. Aberrant DNA methylation in cancer: Potential clinical intervenetions [J]. Expert Rev Mol Med, 2002, 4(04):1-17.
[9] Bird A. Perceptions of epigenetics [J]. Nature, 2007, 447(7143):396-398.
[10] Yoonki H, Woo J K. DNA methylation Markers in lung cancer[J]. Current Genomics, 2021, 22(2):79-87.
[11] LI Y, LYU Z, ZHAO L, et al. Prognostic value of MGMT methylation in colorectal cancer: A meta-analysis and literature review[J]. Tumour Biol, 2015, 36(3):1595-1601.
[12] Asiaf A, Ahmad S T, Malik A A, et al. Protein expression and methylation of MGMT, a DNA repair gene and their correlation with clinicopathological parameters in invasive ductal carcinoma of the breast[J]. Tumour Biol, 2015(5):254 -260.
[13] Esteller M. Epigeneties in cancer [J]. N Engl J Med, 2008, 358(11):1148-1159.
[14] Sidiropoulos M, Pampalakis G, Sotiropulou G, et a1. Down regulation of human kallikrein 10(KLKl0/NESI) by CpG island hypermethylation in breast, ovarian and prostate cancers[J]. Tumour Biol, 2005, 26(6): 324-336.
[15] Nascimento Borges B, Burbano R M, Harada M L. Analysis of the methylation patterns of the p16 INK4A, p15 INK4B, and APC genes in gastric adenocarcinoma patients from a Brazilian population[J]. Tumor Biology, 2013, 34(4):2127-2133.
[16] Bodoor K, Haddad Y, AlkhateebA, et al. DNA hypermethylation of cell cycle (p15 and p16) and apoptotic (p14, p53, DAPK and TMS1) genes in peripheral blood of leukemia patients[J]. Asian Pac J Cancer Prev, 2014, 15(1):75-84.
[17] Cecener G, Tunca B, Egeli U, et al. The promoter hypermethylation status of GATA6,MGMT,and FHIT in glioblastoma[J]. Cell Mol Neurobiol, 2012, 32(2): 237-244.
[18] Thomas Vaissie-re, Rayjean J Hung, David Zaridze, et al. Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors[J]. Cancer Res, 2009, 69 (1):243-252.
[19] XING X, CAI W, SHI H, et al. The prognostic value of CDKN2A hypermethylation in colorectal cancer: A meta-analysis[J]. Br J Cancer, 2013, 108(12): 2542-2548.
[20] Arya A K, Bhadada S K, Singh P, et al. Promoter hypermethylation inactivates CDKN2A, CDKN2B and RASSF1A genes in sporadic parathyroid adenomas [J]. Sci Rep, 2017, 7(1): 3123.
[21] Chenevix Trench G, Healey S, Lakhani S, et al. Genetic and histopathologic evaluation of BRCA1 and BRCA2 DNA sequence variants of unknown clinical significance[J]. Cancer Res, 2006, 66(2): 2019-2027.
[22] YANG B, GUO M, Herman J G, et al. Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma[J]. Am J Pathol, 2003, 163(3): 1101-1107.
[23] Paz M F, Fraga M F, Avila S, et al. A systematie profile of DNA methylation in human cancer cell lines[J]. Cancer Res, 2003, 63(5):1114-112.
[24] Manel E, Fraga M F, Guo M, et al. DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis[J]. Human Molecular Genetics, 2001, 10(26):3001-3007.
[25] Laird P W. The power and the promise of DNA methylation markers[J]. Nature Reviews Cancer, 2003, 3(4):253-266.
[26] Cairns P, Esteller M, Herman J G, et al. Molecular detection of prostate cancer inurine by GSTPI hypermethylation[J]. Clin Cancer Res, 2001, 7(9):2727-2730.
[27] Hoque M O. Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects[J]. J Clin Oncol, 2005, 23(27):6569-6975.
[28] Belinsky S A, Schiller J H, Stidley C A. DNA methylation biomarkers to assess therapy and chemoprevention for non-small cell lung cancer[J]. Nutrition Reviews, 2008(suppl-1): S24-S26.
[29] Belinsky S A, Liechty K C, Gentry F D, et al. Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort[J]. Cancer Research, 2006, 66(6):3338-3344.
[30] Nagaraja S S, Nagarajan D. Radiation-Induced pulmonary epithelial mesenchymal transition: A review on targeting molecular pathways and mediators [J]. Curr Drug Targets, 2018, 19(10): 1191-204.
[31] ICRP. The 2007 recommendations of the International Commission on Radiological Protection[R]. ICRP publication 103. Annals of the ICRP, 2007(37).
[32] Priya Rashmi, Das Birajalaxmi. Global DNA methylation profile at LINE-1 repeats and promoter methylation of genes involved in DNA damage response and repair pathways in human peripheral blood mononuclear cells in response to γ radiation[J]. Molecular and Cellular Biochemistry, 2022, 477(1):267-281.
[33] Chi H C , Tsai C Y, Tsai M M, et al. Impact of DNA and RNA methylation on radiobiology and cancer progression[J]. Int J Mol Sci, 2018, 19(2):555-577.
[34] Lee Y, Kim Y J, Choi Y J, et al. Radiation-induced changes in DNA methylation and their relationship to chromosome aberrations in nuclear power plant workers[J]. International Journal of Radiation Biology, 2015, 91(2):142-149.
[35] Kuzmina N S, Lapteva N S, Rubanovich A V. Hypermethylation of gene promoters in peripheral blood leukocytes in humans long term after radiation exposure[J]. Environmental Research, 2016 (146):10-17.
[36] Daniel J W, Ranjani L, Gangning Liang. The role of DNA methylation and DNA methyltransferases in cancer[J]. Advances in Experimental Medicine and Biology, 2022, 1389: 317-348.
[37] 石大伟, 赵永成. 电离辐射诱导的DNA甲基化模式改变及其在辐射致癌机制研究中的意义[J].国际放射医学核医学杂志, 2006, 30(4): 240-243.
SHI D W, ZHAO Y C. Radiation-induced DNA methylation profile changes and its impact on mechanisms of radiation carcinogenesis[J]. Int J Radiat Med Nucl Med, 2006, 30(4): 240-243.
[38] Tokarskaya Z B, Okladnikova N D, Belyaeva Z D, et al. The influence of radiation and non-radiation factors on the lung cancer incidence among the workers of the nuclear enterprise Mayak[J]. Health Phys, 1995, 69(3):356-366.
[39] Steven A Belinsky, Donna M Klinge, Kieu C Liechty, et al. Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinoma[J]. Carcinogenesis, 2004, 25(6):1063-1067.
[40] Steven A Belinsk. Molecular markers of lung cancer in workers from the MAYAK nuclear enterprise: Final report[R]. The Report of UNT Libraries Government Documents Department, February 15, 2007.
[41] Kuzmina N S, Lapteva N S, Rusinova G G, et al. Gene hype-methylation in blood leukocytes in humans long term after radiation exposure-Validation set[J]. Environ Pollut, 2018, 234: 935-942.
[42] Lees-Miller S P, Sakaguchi K, Ullrich S J, et al. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53[J]. Molecular and Cellular Biology, 1992, 12(11):5041-5049.
[43] 周平坤,霍艳英,吴德昌. 辐射致癌效应与机制[J]. 辐射防护通讯, 2007, 27(01):7-12.
ZHOU Pingkun, HUO Yanying, WU Dechang. Radiation carcinogenesis and its mechanisms[J]. Radiation Protection Bulletin, 2007, 27(01):7-12.
[44] Rountree M R, Bachman K E, Herman J G, et al. DNA methylation, chromatin inheritance and cancer [J]. Oncogene, 2001, 20(24): 3156-3165.
[45] Yamada Y, Nakata A. Implication of p16 inactivation in tumorigenic activity of respiratory epithelial cell lines and adenocarcinoma cell line established from plutonium-induced lung tumor in rat[J]. In Vitro Cellular & Developmental Biology-Animal, 2010, 46(5):477-486.
[46] 隋建丽,范保星,孙敬芬,等. α粒子诱发人支气管上皮细胞癌变的DNA修复基因表达谱研究[J]. 癌变·畸变·突变, 2004, 16(5):257-259.
SUI Jianli, FAN Baoxing, SUN Jingfen, et al. Investigation of DNA repair gene expression pattern of radiation-induced[J]. Carcinogenesis, Teratogenesis and Mutagenesisi, 2004, 16(5):257-259.
[47] SUI J L, AN J, SUN J F, et al. Spindle checkpoint and apoptotic response in α-particle transformed human bronchial epithelial cells[J]. Radiation & Environmental Biophysics, 2004, 43(4):257-263.

Research progress of DNA methylation in plutonium radiation damage mechanisms

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