胞外超氧化物歧化酶(EC-SOD)抗辐射作用的研究进展

Abstract

Abstract: The tissue and organ damage process caused by electromagnetic radiation, ionizing radiation, optical radiation, and other radiation is often accompanied by reactive oxygen species (ROS) activation and DNA damage. Superoxide dismutase (SOD) is an antioxidant metalloenzyme that exists in the organism, which plays a vital role in the body’s oxidant/antioxidant balance, and participates in the occurrence and development of many diseases. Extra-cellular superoxide dismutase (EC-SOD) is mainly found in the extra-cellular matrix. Many studies have demonstrated that EC-SOD plays a protective role in radiation damage to a variety of tissues and organs, which mainly prevents further damage to cells and tissues by reducing ROS levels, anti-angiogenesis, anti-chemotactic and anti-inflammatory. Therefore, we have reviewed the protective role and mechanism of EC-SOD and its mimetics or analogues in radiation protection, and provide a theoretical reference for the application of EC-SOD with radiation resistance.

Key words: extra-cellular superoxide dismutase (EC-SOD), radiation injury, radiation resistance, reactive oxygen species(ROS)

CLC Number:

R142+.4

ZHU Mengmei, OUYANG Tao, HUA Tianzhen, LI Kun, YU Bing. Research progress of EC-SOD radiation resistance[J].RADIATION PROTECTION, 2022, 42(2): 102-110.

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Research progress of EC-SOD radiation resistance

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