海带多糖对受照小鼠脑血管损伤的保护作用

RADIATION PROTECTION ›› 2019, Vol. 39 ›› Issue (3): 249-253.

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Protective effect of Laminaria Japonica Polysaccharideson vessel in cerebral cortex

CHAI Rong¹, ZHANG Siqin¹,LIU Wenqi², XU Yang¹, WEI Li^3,4, CHEN Chen¹, FU Zhenlin³

1.College of Stomatology, Guangxi Medical University, Nanning 530021;
2.Department of Radiology, The Second Affiliated of Guangxi Medical University, Nanning 530021;
3.Department of Human Anatomy, Guangxi Medical University, Nanning 530021;
4.Guangxi Key Laboratory of Regenerative Medicine, Nanning 530021

Received:2018-08-29 Online:2019-05-15 Published:2019-10-29

Abstract

Abstract: In order to observe the effect of Laminaria Japonica Polysaccharides (LJP) on microglia and vessel in cerebral cortex after radiation,120 female Kunming mice were randomly divided into four groups:control group, LJP group, radiation group and LJP+radiation group. The model of radiation-induced brain injury of mice was established by using ⁶⁰Co γ ray. The mice in the radiation and LJP+radiation groups were injected intraperitoneally with LJP at the dose of 100 mg/kg body weight everyday, while those in the control and LJP groups received solvent only. At 1 day, 7 day and 14 day after localized irradiation, brain tissues were collected for immunohistochemistry. Results showed that Laminaria japonica polysaccharides can effectively inhibit microglia activation and increase microvessel density in the cerebral cortex after irradiation. Laminaria japonica polysaccharides may be expected to become a safe and effective radiation protect agent.

Key words: Laminaria Japonica Polysaccharides, microvessel density, microliga, radiation-induced brain injury

CLC Number:

R142+.4

CHAI Rong, ZHANG Siqin,LIU Wenqi, XU Yang, WEI Li, CHEN Chen, FU Zhenlin. Protective effect of Laminaria Japonica Polysaccharideson vessel in cerebral cortex[J].RADIATION PROTECTION, 2019, 39(3): 249-253.

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Protective effect of Laminaria Japonica Polysaccharideson vessel in cerebral cortex

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