RADIATION PROTECTION ›› 2016, Vol. 36 ›› Issue (2): 76-81.

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Estimation of radiogenic colon cancer risk coefficients for Chinese population

Sun Zhijuan1, Wang Jixian1, Sun Quanfu2, Xiang Jian1, Zhao Yongcheng1, Zhang Xin1, Tuo Ya1, Fan Saijun1   

  1. 1. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin 300192;
    2. Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088
  • Received:2015-05-22 Online:2016-03-20 Published:2021-11-12

Abstract: To estimate sex-age specific excess relative risk coefficients of colon cancer due to ionizing radiation for Chinese population, the following models and data were used, such as the risk models developed by BEIR Ⅶ committee (Biological Effect of Ionizing Radiation), population risk transfer model composed with both multiplicative and additive model and 2009 Chinese colon cancer baseline incidence. To obtain sex-age specific colon cancer baseline incidence, a curve fitting based on age group specific data was used. Excess relative risk coefficients of colon cancer for Chinese population are overall higher than that of Life Span Study in Japan and their sex-age tendency are similar. Excess relative risk coefficients here could provide key basis data for lifetime risk prediction and radiogenic causation judgment for colon cancer of Chinese population.

Key words: radiation carcinogen, risk transportation model, baseline cancer incidence, colon cancer

CLC Number: 

  • R146