TGF-β1对放射性肺纤维化作用的研究进展

辐射防护 ›› 2018, Vol. 38 ›› Issue (2): 171-176.

TGF-β1对放射性肺纤维化作用的研究进展

陈志远, 董卓, 魏威, 吕亚慧, 王蕊, 袁铭成, 金顺子

吉林大学公共卫生学院卫生部放射生物学重点实验室,长春 130021

收稿日期:2017-01-28 出版日期:2018-03-20 发布日期:2020-07-20
作者简介:陈志远(1991—),男,2016年毕业于滨州医学院预防医学专业,现为吉林大学公共卫生学院放射医学硕士研究生。E-mail:1206912736@qq.com
通讯作者:金顺子。E-mail:jinsz@jlu.edu.cn
基金资助:
国家自然科学基金资助项目(项目号81573085,81371890)。

Research progress of TGF-β1 on radiation-induced pulmonary fibrosis

CHEN Zhiyuan, DONG Zhuo, WEI Wei, LU Yahui, WANG Rui, YUAN Mingcheng, JIN Shunzi

Key Laboratory of Radiation Biology, Ministry of Health, School of Public Health, Jilin University, Changchun 130021

Received:2017-01-28 Online:2018-03-20 Published:2020-07-20

摘要/Abstract

摘要： 转化生长因子-β1(TGF-β1)在肺纤维化发展过程中介导复杂的促进纤维化信号通路,特别是在肺组织的损伤修复中,TGF-β1作为重要的细胞生长因子起到重要作用,它可激活成纤维细胞,促进基质合成,产生大量胶原蛋白。放射性肺损伤是在肺部疾病的放射治疗中常见的并发症,早期表现为放射性肺炎,晚期表现为放射性肺纤维化。了解和掌握TGF-β1在肺纤维化的发生、发展中的分子机制,对防治肺纤维化,减少并发症的发生具有重要意义。本文对TGF-β1在放射性肺纤维化中作用的分子机制及治疗进展进行综述。

关键词: 转化生长因子-β1(TGF-β1), 放射性肺纤维化, 分子机制

Abstract: Transforming growth factor-β1 (TGF-β1) mediates complex fibrotic signaling pathways during the development of pulmonary fibrosis. Especially in the repair of lung tissue injury, TGF-β1, as an important cell growth factor plays an important role, can activate fibroblasts and promote matrix synthesis, resulting in a large number of collagen. Radiation induced lung injury is a common complication in radiotherapy of lung disease. Early manifestations are radioactive pneumonia and advanced manifestations are radioactive pulmonary fibrosis. Understanding of the molecular mechanism of TGF-β1 in the pathogenesis and progression of pulmonary fibrosis is of great significance to prevent, treat pulmonary fibrosis and reduce the incidence of complications. In this paper, the molecular mechanism of TGF-β1 in the role of radiation pulmonary fibrosis and treatment progress were reviewed.

Key words: TGF-β1, radioactive pulmonary fibrosis, molecular mechanism

中图分类号:

R811.5

陈志远, 董卓, 魏威, 吕亚慧, 王蕊, 袁铭成, 金顺子. TGF-β1对放射性肺纤维化作用的研究进展[J]. 辐射防护, 2018, 38(2): 171-176.

CHEN Zhiyuan, DONG Zhuo, WEI Wei, LU Yahui, WANG Rui, YUAN Mingcheng, JIN Shunzi. Research progress of TGF-β1 on radiation-induced pulmonary fibrosis[J]. RADIATION PROTECTION, 2018, 38(2): 171-176.

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