γ射线对比格犬凝血功能的影响

辐射防护通讯 ›› 2021, Vol. 41 ›› Issue (5): 24-27.

γ射线对比格犬凝血功能的影响

李曙芳, 岳娟, 许文黎, 黄立群, 王志鹏, 孙鸽, 胡波

中国辐射防护研究院GLP中心,太原,030006

收稿日期:2021-08-16 出版日期:2021-10-20 发布日期:2022-03-31
通讯作者: 胡波,E-mail:hhhbbb_1@163.com
作者简介:李曙芳(1983—),女,2009年毕业于山西医科大学卫生毒理学专业,硕士。副研究员。

Effects of Gamma Rays on Coagulation Function of Beagle

Li Shufang, Yue Juan, Xu Wenli, Huang Liqun, Wang Zhipeng, Sun Ge, Hu Bo

GLP Centre,China Institute for Radiation Protection,Taiyuan,Shanxi 030006

Received:2021-08-16 Online:2021-10-20 Published:2022-03-31

摘要/Abstract

摘要： 比格犬受到⁶⁰Co γ射线不同剂量(2、3、4 Gy)单次全身单侧照射后,观察不同时间血小板和凝血功能指标的变化情况。结果表明,2 Gy和4 Gy照射均可启动内源性凝血机制、形成血栓继而出现纤溶亢进,而4 Gy照射引发出血死亡的机制与血凝、抗凝和纤维蛋白溶解系统障碍有关。

关键词: γ射线, 比格犬, 凝血功能

Abstract: After systemic unilateral exposure to ⁶⁰Co with different doses,the changes of platelets and coagulation function in beagles were observed at different times. The results showed that both low and high dose could activate endogenous coagulation mechanism,thrombosis and fibrinolysis hyperactivity,and the mechanism of bleeding death induced by high dose was related to the disorder of blood coagulation,anticoagulation and fibrinolysis system.

Key words: Gamma rays, Beagle, Coagulation function

中图分类号:

R818.03

李曙芳, 岳娟, 许文黎, 黄立群, 王志鹏, 孙鸽, 胡波. γ射线对比格犬凝血功能的影响[J]. 辐射防护通讯, 2021, 41(5): 24-27.

Li Shufang, Yue Juan, Xu Wenli, Huang Liqun, Wang Zhipeng, Sun Ge, Hu Bo. Effects of Gamma Rays on Coagulation Function of Beagle[J]. RADIATION PROTECTION BULLETIN, 2021, 41(5): 24-27.