放射性骨丢失机制与防护研究进展

摘要/Abstract

摘要： 放射治疗可引起照射部位骨组织产生放射性骨损伤,发生骨丢失、骨质疏松,甚至病理性骨折。放射性骨丢失的主要原因是电离辐射可促进破骨细胞的骨吸收过程,抑制成骨细胞的骨形成过程。根据电离辐射对骨组织细胞影响的具体机制,以及骨组织细胞对不同剂量的电离辐射的不同响应,可采取相应的治疗和防护措施。本文从动物水平和细胞水平两个方面介绍放射性骨丢失的研究进展,并针对其发生机制提出可能的防护措施。

关键词: 电离辐射, 骨丢失, 骨组织细胞, 辐射防护

Abstract: Radiotherapy may cause radiation-induced bone damagein the irradiated area, including bone loss, osteoporosis and even pathological fracture. The main causefor bone loss of this type is that ionizing radiation can promotebone resorption of osteoclasts and inhibit genesis of osteoblasts. On account of specific mechanisms involved, and theresponses of bone tissue cells to different radiation doses, corresponding treatment and protective measures should be taken. Advances in research of radiation-induced bone loss and its protection at both animal and cell levels was reviewed accordingly.

Key words: Ionizing radiation, Bone loss, Bone tissue cells, Radiation protection

中图分类号:

R852.7

邱新宇, 闫玉洁, 奚可迪, 张琨岚, 胡文涛, 张健. 放射性骨丢失机制与防护研究进展[J]. 辐射防护通讯, 2019, 39(2): 23-33.

Qiu Xinyu, Yan Yujie, Xi Kedi, Zhang Kunlan, Hu Wentao, Zhang Jian. Research Progress on Radiation-induced Bone Loss and its Protection[J]. RADIATION PROTECTION BULLETIN, 2019, 39(2): 23-33.

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