Abstract: To evaluate the therapeutic effect of hyperbaric oxygen therapy on radiodermatitis induced by image-guided radiotherapy (IGRT) for breast cancer. The patients with radiodermatitis from breast cancer treated in the First Affiliated Hospital of Hebei North University from November 2023 to April 2025 were enrolled. After undergoing modified radical mastectomy, the patients underwent IGRT calibrated with cone-beam CT and were randomly divided into the test group and the control group. The control group received conventional interventions, while the test group received additional hyperbaric oxygen therapy. the level of radiodermatitis, dermatology life quality index, and incidence of adverse events were compared between the two groups from Week 1 to Week 12. Statistical analysis showed that both the levels and dermatology life quality index were higher in the control group than those in the test group from Week 8 to Week 10 (P<0.05), while there was no difference in the incidence of adverse events between the two groups (P>0.05). Hyperbaric oxygen therapy reduced the levels of radiodermatitis and dermatology life quality index caused by IGRT for breast cancer, demonstrating its clinical value.

Key words: breast neoplasms, image-guided radiotherapy, hyperbaric oxygen, radiodermatitis