Abstract: When an acute high intake of radionuclide has occurred or is going to occur in the dose range close to deterministic effect (or tissue reaction), it is needed for a technical platform or tool used to quickly estimate the short-term absorbed dose in interested organs or tissues, in order to make decision for nuclear and radiation response actions and other response actions suggested by IAEA Safety Guide No.GSG-2, which can minimize large radiation dose to the people exposed and then protect the health of the people actually. Therefore this paper focuses on the followings: studying the designing principle and models’ parameters foundation of the International Commission on Radiological Protection (ICRP) Human Respiratory Tract Model (HRTM), Systemic Model, Human Alimentary Tract Model (HATM) and Wound Model; compiling the retention and excretion fraction m(t) calculation codes, after its verification, to calculate the target organ’s RBE weighted absorbed dose AD(30)_T for an urgent inhalation of ²⁴¹Am, and the correctness of the results are ensured by comparison of two persons’ results.

Key words: biokinetic models, RBE weighted, absorbed dose coefficient, retention and excretion fractions, verifying, deterministic effect, ²⁴¹Am