世界高本底辐射地区流行病学、剂量学和放射生物学问题的回顾

Abstract

Abstract: Radiation levels therefore vary from one region of the world to another. Naturally occurred high background radiation areas, due to the uniqueness of their radiation doses and the populations that inhabit, has always been attracting the attention of researchers from different countries. Early epidemiological studies did not show an increasing trend in cancer incidence in high natural background radiation areas, raising some controversy about the validity of the linear non-threshold hypothesis. This paper presents and discusses the main results of radioactivity level measurements, radiobiological and radiation epidemiological studies conducted in some of the major areas with high natural background radiation areas of the world, such as China, Brazil, India and Iran. It is hoped that research interest will be aroused in the topical issues of dosimetry, epidemiology and radiobiology related to the high natural background radiation areas of the world. Recommendations to address the problems faced at this stage, in order to achieve better research related to high natural background radiation areas. At the same time, the inhabitants of high natural background radiation areas are protected from possible radiation exposure.

Key words: high natural background radiation areas, radiation epidemiology, radiation dose, radiobiology

CLC Number:

XUE Huiyuan, GAO Jin, TU Yu. Review of radiation epidemiology, dosimetry and radiobiology in areas with high natural background radiation areas of the world[J].RADIATION PROTECTION, 2023, 43(S1): 129-138.

References 86

[1]	Aliyu A S, Ramli A T. The world’s high background natural radiation areas (HBNRAs) revisited: A broad overview of the dosimetric, epidemiological and radiobiological issues[J]. Radiation Measurements, 2015,73: 51-59.
[2]	Sohrabi M. The state-of-the-art on worldwide studies in some environments with elevated Naturally Occurring Radioactive Materials (NORM)[J]. Applied Radiation and Isotopes, 1998,49(3): 169-188.
[3]	Sohrabi M. World high background natural radiation areas: Need to protect public from radiation exposure[J]. Radiation Measurements, 2013,50: 166-171.
[4]	Mortazavi S M J. Peripheral blood lymphocyte micronucleus frequencies in men from areas of Kerala, India, with high vs normal levels of natural background ionizing radiation[J].Mutation Research/genetic Toxicology & Environmental Mutagenesis, 2016,808:52-3.
[5]	陈德清, 戴连连, 刘青杰, 等. 阳江天然高本底辐射诱导人体淋巴细胞适应性反应[J]. 中华放射医学与防护杂志, 1999,19(2): 18-20.
[6]	Veiga L H S, Koifman S. Pattern of cancer mortality in some Brazilian HBRAs[J]. International Congress Series, 2005,1276: 110-113.
[7]	Attar M, Molaie K Y, Khansari N. Effect of high dose natural ionizing radiation on the immune system of the exposed residents of Ramsar Town, Iran[J]. Iran J Allergy Asthma Immunol, 2007,6(2): 73-78.
[8]	李坤, 李小娟, 王海军, 等. 阳江天然放射性高本底地区居民血清免疫学调查研究[J]. 中国预防医学杂志, 2013,14(10): 774-778.
[9]	Jain V, Kumar P R V, Koya P K M, et al. Lack of increased DNA double-strand breaks in peripheral blood mononuclear cells of individuals from high level natural radiation areas of Kerala coast in India[J]. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2016,788: 50-57.
[10]	张品华. 低剂量辐射对miRNAs及细胞周期相关靶基因的影响[D]. 中国疾病预防控制中心, 2017.
[11]	袁镛龄, 沈泓. 阳江高本底辐射地区的个人外照射剂量估算和人员的剂量分组[J]. 中华放射医学与防护杂志, 1999, 19(2):5.
[12]	袁镛龄, 森岛弥重, 沈泓, 等. 阳江高本底辐射地区环境中氡及其子体的测量[J]. 中国辐射卫生, 2000(1): 1-3.
[13]	袁镛龄, 森岛弥重, 沈泓, 等. 天然辐射源致阳江高本底辐射地区居民的剂量估算[J]. 中国辐射卫生, 2004(1): 1-7.
[14]	李小亮, 赵锡鹏, 赵玉倩, 等. 广东阳江高本底地区γ辐射水平调查[J]. 中国辐射卫生, 2018,27(5): 427-429.
[15]	苏世标, 邹剑明, 耿继武, 等. 高本底辐射居民DNA损伤修复能力研究[J]. 中国职业医学, 2010,37(1): 15-17.
[16]	袁镛龄, 森岛弥重, 沈泓, 等. 阳江天然高本底辐射地区空气中氡浓度的分布特征[J]. 中国辐射卫生, 2001(1): 5-7.
[17]	袁镛龄, 沈泓, 赵士庵, 等. 阳江天然放射性高本底地区剂量调查的新进展[J]. 中华放射医学与防护杂志, 1995,15(5): 311-316.
[18]	陶祖范, 秋叶澄伯, 查永如, 等. 阳江高本底地区恶性肿瘤死亡调查1987—1995年资料分析[J]. 中华放射医学与防护杂志, 1999,9(2): 6-9.
[19]	邹剑明. 广东阳江高本底地区居民癌症及其相关因素研究主要结果[J]. 中国职业医学, 2004(3): 6-9.
[20]	李小亮, 李坤, 孙全富, 等. 阳江天然高本底辐射地区居民端粒长度初步研究[J]. 中华放射医学与防护杂志, 2017,37(11): 853-857.
[21]	王海军. 阳江高本底地区辐射致癌危险分析及居民免疫功能检测[D]. 中国疾病预防控制中心, 2009.
[22]	邹剑明, 姚军, 陈念光, 等. 阳江高本底地区居民中免疫水平与对病毒免疫反应的研究[J]. 中华放射医学与防护杂志, 1997,17(6): 34-38.
[23]	陈德清, 姚素艳, 张朝阳, 等. 阳江高本底辐射对不同年龄居民染色体畸变的影响[J]. 中华放射医学与防护杂志, 1997,17(6): 21-24.
[24]	黎丽春, 邹剑明, 苏世标, 等. 阳江高本底辐射对居民机体MGMT基因和T-AOC的影响[J]. 中国热带医学, 2010,10(04): 415-416.
[25]	邹剑明, 孙全富, 袁镛龄, 等. 阳江天然放射性高本底和对照地区居民鼻咽癌死亡病例对照研究[J]. 中华放射医学与防护杂志, 1999,19(2): 21-25.
[26]	王海军, 孙全富, 秋葉澄伯,等. 阳江高本底地区辐射致癌危险分析(1979—2002年)[J]. 中华放射医学与防护杂志, 2016, 36(1):7.
[27]	袁桂清. 阳江高本底放射地区1979—1995年恶性肿瘤死亡调查分析[J]. 中华医学信息导报, 1999(13):1.
[28]	孙全富, 秋叶澄伯, 陶祖范, 等. 阳江天然放射性高本底辐射慢性照射与实体癌超额危险[J]. 中华放射医学与防护杂志, 2002,22(1): 55-58.
[29]	邹剑明, 孙全富, 袁镛龄. 阳江高本底地区居民鼻咽癌危险因素的巢式病例对照研究[J]. 中国辐射卫生, 2003(1): 1-3.
[30]	王海军, 邹剑明, 孙全富, 等. 阳江高本底地区肺癌与室内氡暴露巢式病例-对照研究[J]. 中国职业医学, 2008(5): 370-373.
[31]	邹剑明, 孙全富, 刘玉升, 等. 阳江天然放射性高本底地区居民1987—1995年非肿瘤死亡再分析[J]. 中华放射医学与防护杂志, 2004,24(2): 63-66.
[32]	李小娟, 孙全富. 阳江天然放射性高本底地区居民1979—1998年肺结核死亡危险分析[J]. 中华放射医学与防护杂志, 2006, 26(5):6.
[33]	苏垠平, 谭光享, 雷淑洁, 等. 阳江高本底女性居民低剂量辐射照射与颈动脉中内膜厚度关系的初步研究[J]. 中华放射医学与防护杂志, 2016,36(9): 682-687.
[34]	李嘉, 菅崎弘之, 杨宇华, 等. 阳江天然放射性高本底地区老年痴呆患病率的调查[J]. 中华放射医学与防护杂志, 1997,17(4): 49-53.
[35]	王焱. 低剂量电离辐射照射与白内障危险关系研究[D].中国疾病预防控制中心,2013.
[36]	苏垠平, 邹剑明, 谭光享, 等. 阳江高本底地区女性居民甲状腺超声检查的结果与分析[J]. 中华放射医学与防护杂志, 2016,36(11): 837-841.
[37]	王春燕, 张伟, 陈德清, 等. 阳江天然高本底辐射地区居民稳定性染色体畸变的研究[J]. 辐射研究与辐射工艺学报, 2002(4): 260-264.
[38]	赵玉倩. 阳江高本底地区女性居民心-踝血管指数横断面研究[D]. 中国疾病预防控制中心, 2018.
[39]	张品华, 高刚, 潘艳,等. 阳江高本底地区居民外周血血浆miRNAs的表达[J]. 中华放射医学与防护杂志, 2017, 37(1):6.
[40]	苏世标, 靳雅丽, 郭强之, 等. 阳江高本底地区居民8-羟基脱氧鸟苷及其修复基因8-羟基鸟嘌呤DNA糖苷酶表达水平[J]. 中国职业医学, 2012,39(6): 467-470.
[41]	李坤. 长期低剂量电离辐射受照人群免疫功能及DNA损伤水平的研究[D]. 中国疾病预防控制中心, 2015.
[42]	耿继武, 苏世标, 温翠菊, 等. 阳江天然高本底辐射地区居民外周血P53蛋白表达的研究[J]. 中国职业医学, 2007(6): 453-455.
[43]	张素萍, 吴昭昭, 武彦文, 等. 广东阳江高本底辐射地区居民适应性反应机制研究[J]. 中华预防医学杂志, 2010,(9): 815-819.
[44]	Vasconcelos D C, Reis P A L, Pereira C, et al. Modelling natural radioactivity in Sand beaches of Guarapari, Espírito Santo State, Brazil[J]. World Journal of Nuclear Science & Technology, 2013, 3(2): 65-71.
[45]	Lauria D C, Godoy J M. Abnormal high natural radium concentration in surface waters[J]. Journal of Environmental Radioactivity, 2002,61(2): 159-168.
[46]	José, Marcus, Godoy, et al. Natural radioactivity in Brazilian groundwater[J]. Journal of Environmental Radioactivity, 2006,85(1): 71-83.
[47]	Marques A L, Geraldo L P, Santos W D J R B. Níveis de radioatividade natural decorrente do radônio no complexo rochoso da Serra de São Vicente, SP[J]. Radiologia Brasileira, 2006, 39(3): 215-218.
[48]	Alexandre Endres M, Julio Alejandro N, Marcos F, et al. Mutagenic potential assessment associated with human exposure to natural radioactivity[J]. Chemosphere, 2017, 167: 36-43.
[49]	Veiga L H S, Koifman S, Melo V P, et al. Preliminary indoor radon risk assessment at the Poços de Caldas Plateau, MG-Brazil[J]. Journal of Environmental Radioactivity, 2003,70(3): 161-176.
[50]	Veiga L H S, Koifman S. Pattern of cancer mortality in some Brazilian HBRAs[J]. International Congress Series, 2005,1276: 110-113.
[51]	Orlando M T D, Cavichini A S, Passos C,et al.Blucher proceedings correlation between breast cancer and radiation level of Guarapari City -ES - Brazil[C]. V Encontro Científico de Física Aplicada,2014.
[52]	Ferreira Rg, Angeli, Mvdd,Barboza Dr, et al. Cancer mortality in Guarapari, Espiríto Santo State, Brazil, with areas of high natural radioactivity[J]. Cadernos De Saude Publica, 2023, 27;39(3): e00089422.
[53]	Martinelli S, Medeiros A N, De Souza R F, et al. Analysis of the cancer occurrence related to natural radioactivity in the Rio Grande do Norte State, Brazil[J]. Environmental Science and Pollution Research, 2023, 30:89140-89152.
[54]	Kendall G M, Smith T J. Doses to organs and tissues from radon and its decay products[J]. Journal of Radiological Protection, 2002, 22(4): 389.
[55]	Řeřicha V, Kulich M, Řeřicha R, et al. Incidence of leukemia, lymphoma, and multiple myeloma in Czech Uranium Miners: A case-cohort study[J]. Environmental Health Perspectives, 2006, 114(6): 818-822.
[56]	Ben Byju S, Koya P K M, Sahoo B K, et al. Inhalation and external doses in coastal villages of high background radiation area in Kollam, India[J]. Radiation Protection Dosimetry, 2012,152(1-3): 154-158.
[57]	Ramasamy V, Sundarrajan M, Paramasivam K, et al. Spatial and depth wise characterization of radionuclides and minerals in various beach sediments from high background radiation area, Kerala, India[J]. Applied Radiation and Isotopes, 2015,95: 159-168.
[58]	Nandakumaran P, Vinayachandran N. A preliminary appraisal of radon concentration in groundwater from the high background radiation area (HBRA) of Coastal Kerala[J]. Journal of the Geological Society of India, 2020,95(5): 491-496.
[59]	Omori Y, Tokonami S, Sahoo S K, et al. Radiation dose due to radon and thoron progeny inhalation in high-level natural radiation areas of Kerala, India[J]. J Radiol Prot, 2017,37(1): 111-126.
[60]	Midhun M, Mathew S, Rejith R S, et al. Comparison of thoron (220Rn) content and gamma radiation level in high background radiation area of Kollam district in Kerala, India[J]. Journal of Radioanalytical and Nuclear Chemistry, 2017,314(1): 177-185.
[61]	Kumar P R V, Seshadri M, Jaikrishan G, et al. Effect of chronic low dose natural radiation in human peripheral blood mononuclear cells: Evaluation of DNA damage and repair using the alkaline comet assay[J]. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2015,775: 59-65.
[62]	Divyalakshmi S, Sudheer K R, Kumar P R V,et al.Evaluation of the influence of chronic low-dose radiation on DNA repair gene polymorphisms[XRCC1, XRCC3, PRKDC (XRCC7), LIG1, NEIL1] in individuals from normal and high level natural radiation areas of Kerala Coast[J].International Journal of Radiation Biology, 2020, 96(6):734-739.
[63]	Jain V, Das B. Global transcriptome profile reveals abundance of DNA damage response and repair genes in individuals from high level natural radiation areas of Kerala coast[J]. PLOS ONE, 2017,12(11): e187274.
[64]	Nishad S, Ghosh A. Comparative proteomic analysis of human peripheral blood mononuclear cells indicates adaptive response to low-dose radiation in individuals from high background radiation areas of Kerala[J]. Mutagenesis, 2018,33(5-6): 359-370.
[65]	Sreekumar A, Jayalekshmi P A, Nandakumar A, et al. Thyroid nodule prevalence among women in areas of high natural background radiation, Karunagappally, Kerala, India[J]. Endocrine, 2020,67(1): 124-130.
[66]	Hosseini T, Fathivand A A, Abbasisiar F, et al. Assessment of annual effective dose from 238U and 226Ra due to consumption of foodstuffs by inhabitants of Tehran city, Iran[J]. Radiat Prot Dosimetry, 2006,121(3): 330-332.
[67]	Pourfallah T A, Babapour H, Shahidi M. Evaluation of high level environmental background radiation areas and its variation in ramsar[J]. Iranian Journal of Medical Physics, 2012,9(2): 87-92.
[68]	Pourfallah T A, Monfared A S, Babapour H, et al. Annual effective dose of high level natural radiation areas of Ramsar[J]. Ifmbe Proceedings,2013(39): 1241-1244.
[69]	Mowlavi A A, Shahbahrami A, Binesh A. Dose evaluation and measurement of radon concentration in some drinking water sources of the Ramsar region in Iran[J]. Isotopes in Environmental and Health Studies, 2009, 45(3):269-272.
[70]	Aghamiri S M R, Ghorbani Z, Darafsheh A, et al. 226Ra concentration in the teeth of habitants of areas with high level of natural radioactivity in Ramsar[J]. Journal of Environmental Radioactivity, 2006,89(3): 212-218.
[71]	Samavat H, Azizian G, Seaward M R D,et al. Radionuclide content of human samples in the Ramsar area of Iran[J].International Journal of Low Radiation, 2006, 3(4):348.
[72]	Mortazavi S, Karam P A. Apparent lack of radiation susceptibility among residents of the high background radiation area in Ramsar, Iran: can we relax our standards?[J]. Radioactivity in the Environment, 2005,7: 1141-1147.
[73]	Monfared A S, Jalali F, Sedaghat S, et al. High natural background radiation areas in Ramsar, Iran: Can inhabitants feel safe?[J]. International Journal of Low Radiation, 2006, 3(2/3):171-177.
[74]	Monfared A S, Jalali F, Mozdarani H, et al. Living in high natural background radiation areas in Ramsar, Iran. Is it dangerous for health?[J]. International Congress Series, 2005,1276: 438-439.
[75]	Mosavi-Jarrahi A, Mohagheghi M, Akiba S, et al. Mortality and morbidity from cancer in the population exposed to high level of natural radiation area in Ramsar, Iran[J]. International Congress Series, 2005,1276: 106-109.
[76]	S M J M, Mozdarani H. Non-linear phenomena in biological findings of the residents of high background radiation areas of Ramsar[J]. International Journal of Radiation Research, 2013,11(1): 3.
[77]	Karam P A. The high background radiation area in Ramsar Iran: Geology, norm, biology, lnt, and possible regulatory fun[C]//Waste Management 2002 Symposium, Tucson, AZ (US), 02/24/2002--02/28/2002.WM Symposia, Inc. Tucson, Arizona, 2002.
[78]	Zakeri F, Rajabpour M R, Haeri S A, et al. Chromosome aberrations in peripheral blood lymphocytes of individuals living in high background radiation areas of Ramsar, Iran[J]. Radiation and Environmental Biophysics, 2011,50(4): 571-578.
[79]	Mortazavi S.Non-linear phenomena in biological findings of the residents of high background radiation areas of Ramsar[J]. International Journal of Radiation Research,2013,11(1):3-9.
[80]	Mohammadi S, Taghavi-Dehaghani M, Gharaati M R, et al. Adaptive response of blood lymphocytes of inhabitants residing in high background radiation areas of Ramsar——Micronuclei, apoptosis and comet assays[J]. Journal of Radiation Research, 2006,47(3/4): 279-285.
[81]	Movahedi R E M. Association of telomere length with chronic exposure to ionizing radiation among inhabitants of natural high background radiation areas of Ramsar, Iran[J]. International Journal of Radiation Biology, 2019, 95(8): 1113-1121.
[82]	Vazifehmand R, Saber S, Takavr A,et al.Effect of high background natural radioactivity on human mitochondrial DNA in Ramsar, the north of Iran[J].International Journal of Low Radiation, 2015, 10(2):169.
[83]	Borzoueisileh S, Monfared A S, Abediankenari S,et al.The comparison of CD4/CD8 ratio among high and ordinary background radiation areas in Ramsar, Iran[J].International Journal of Low Radiation, 2011, 8(4):329.
[84]	Ghiassi-Nejad M, Mortazavi S M J, Cameron J R,et al.Very high background radiation areas of Ramsar, Iran: preliminary biological studies[J].Health Physics, 2002, 82(1):87-93.
[85]	Masoomi J R, Mohammadi S, Amini M, et al. High background radiation areas of Ramsar in Iran: evaluation of DNA damage by alkaline single cell gel electrophoresis (SCGE)[J]. Journal of Environmental Radioactivity, 2006,86(2): 176-186.
[86]	Borzoueisileh S, Monfared A S, Abediankenari S,et al. The assessment of cytotoxic T cell and natural killer cells activity in residents of high and ordinary background radiation areas of Ramsar-Iran[J]. J Med Phys, 2013, 38(1):30-33.

Review of radiation epidemiology, dosimetry and radiobiology in areas with high natural background radiation areas of the world

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