川陕花椒根皮提取物对人角质形成细胞辐射损伤的防护作用

Abstract

Abstract: Radiation-induced skin injury is a common complication of patients receiving radiotherapy. Its pathogenesis is complicated and varies greatly with individual patients. Therefore, it is necessary to develop the drugs for prevention and treatment of radiation-induced skin injury. Chinese prickly ash (Zanthoxylum bungeanum) is a common medicine used for skin diseases in traditional Chinese medicine. In this study, the radio-protective effect of the root bark extract of Zanthoxylum piasezkii (ZPE) on HaCaT was investigated and its mechanism was preliminary discussed. The results showed that 2 mg/mL ZPE could protect HaCaT cells from damage induced by 8.0 Gy γ ray irradiation, and could reduce apoptosis and necrosis of HaCaT cells. The mechanism may be related to the reduction of the secretion of IL-1β and IL-6, the level of ROS and the phosphorylation of p38 and JNK proteins. This work provides a theoretical basis for the development of preventive and therapeutic drugs for radiation-induced skin injury.

Key words: Radiation-induced skin injury, Zanthoxylum piasezkii, radiation protection, human keratinocytes

CLC Number:

R818

WANG Chengfang, QI Xuesong, SHAO Shuai, DU Shushan, GOU Qiao. Protective effects of extract from the root bark of Zanthoxylum piasezkii on radiation injury of human keratinocytes[J].RADIATION PROTECTION, 2023, 43(6): 657-664.

References

[1] YANG X, REN H, GUO X, et al. Radiation-induced skin injury: pathogenesis, treatment, and management[J]. Aging(Albany NY), 2020, 12(22):23379-23393.
[2] Spitz D R, Azzam E I, Li J J, et al. Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology[J]. Cancer Metast Rev, 2004, 23(3-4): 311-322.
[3] Radvansky L J, Pace M B, Siddiqui A. Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia[J]. Am J Health-SystPh, 2013, 70(12): 1025-1032.
[4] Singh M, Alavi A, Wong R, et al. Radiodermatitis: a review of our current understanding[J]. Am J Clin Dermatol, 2016, 17(3): 277-292.
[5] 曾小玲,盛小伍,周晓,等. 急性放射性皮炎防治研究进展[J]. 肿瘤药学,2021,11(5):524-529.
ZENG Xiaoling, SHENG Xiaowu, ZHOU Xiao, et al. Progress in prevention and treatment of acute radiation dermatitis[J]. Anti-Tumor Pharmacy, 2021,11(5):524-529.
[6] Patil K, Mallya R. Genus Zanthoxylum as sources of drugs for treatment of tropical parasitic diseases[J]. Curr Drug Discov Technol, 2022, 19(3): e040322201773.
[7] HAO D, WEN X, LIU L,et al. Sanshool improves UVB-induced skin photodamage by targeting JAK2/STAT3-dependent autophagy[J]. Cell Death Dis, 2019, 10(1):19. doi.org/10.1038/s41419-018-1261-y.
[8] 陈丹丹. 花椒挥发油的研究进展及开发前景[J]. 基层医学论坛,2013(31):4180-4182.
[9] 张彦昕,勾文峰,李欣,等. 中药制剂治疗放射性皮炎的研究进展[J]. 辐射防护通讯,2021,41(3):1-9.
ZHANG Yanxi, GOU Wenfeng, LI Xin, et al. Research progress of traditional chinese medicine preparations in the treatment of radiodermatitis[J]. Radiation Protection Bulletin, 2021,41(3):1-9.
[10] Santhanam R K, Fakurazi S, Ahmad S, et al. Inhibition of UVB-induced pro-inflammatory cytokines and MMP expression by Zanthoxylum rhetsa bark extract and its active constituent hesperidin[J]. Phytother Res, 2018, 32(8):1608-1616.
[11] 程晓妮,潘亚磊,唐志书,等. 中药抗辐射及机制研究新进展[J]. 中南药学,2020,18(11):1846-1851.
[12] Kery M, Papandreou I. Emerging strategies to target cancer metabolism and improve radiation therapy outcomes[J].Br J Radiol, 2020, 93(1115): 20200067.
[13] Radvansky L J, Pace M B, Siddiqui A. Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia[J]. American Journal of Health-System Pharmacy, 2013, 70(12): 1025-1032.
[14] Müller K, Meineke V. Radiation-induced alterations in cytokine production by skin cells[J]. Exp Hematol, 2007, 35(4): 96-104.
[15] Kim E K, Choi E J. Compromised MAPK signaling in human diseases: an update[J]. Arch Toxicol, 2015, 89(6):867-882.
[16] Guo R H, Park J U, Jo S J, et al. Anti-allergic inflammatory effects of the essential oil from fruits of Zanthoxylum coreanum Nakai[J]. Front Pharmacol, 2018,(12)9: 1441.
[17] CHEN J M, CHEN P Y, LIN C C, et al. Antimetastatic effects of sesamin on human head and neck squamous cell carcinoma through regulation of matrix metalloproteinase-2[J]. Molecules, 2020, 25(9): 2248.
[18] Gunter N V, Teh S S, Lim Y M, et al. Natural xanthones and skin inflammatory diseases: multitargeting mechanisms of action and potential application[J]. Front. Pharmacol, 2020, 11:594202.

[1]	. [J]. RADIATION PROTECTION, 2022, 42(6): 637 -640 .
[2]	. [J]. RADIATION PROTECTION, 2023, 43(6): 0 .
[3]	. [J]. RADIATION PROTECTION, 2023, 43(6): 670 .
[4]	. [J]. RADIATION PROTECTION, 2023, 43(6): 541 .
[5]	ZHAO Ri, LIU Zhaoxing, LIU Na, WANG Xianxiang, ZHANG Jing, LIANG Runcheng, LIU Xin, LINGHU Renjing, DAI Yuling. A new generation of human radiation dose calculation technology based on deformable mesh-type phantom[J]. RADIATION PROTECTION, 2023, 43(6): 533 -541 .
[6]	. [J]. RADIATION PROTECTION, 2023, 43(6): 548 .
[7]	. [J]. RADIATION PROTECTION, 2023, 43(6): 619 .
[8]	. [J]. RADIATION PROTECTION, 2023, 43(6): 633 .
[9]	SONG Honghu, WU Zhen, QIU Rui, WEI Shuoyang, GONG Hui, ZHANG Hui, LI Junli. Study on the diamond dose measurement device for X-rays generated from ultrashort and ultra-intense laser facility[J]. RADIATION PROTECTION, 2023, 43(6): 542 -548 .
[10]	. [J]. RADIATION PROTECTION, 2023, 43(6): 641 .

Protective effects of extract from the root bark of Zanthoxylum piasezkii on radiation injury of human keratinocytes

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10

[1]	WANG Yaxiao, LI Zhuoran, WANG Bingheng, WANG Xiaoxia, GAO Guiling. Research on key issues of radiation protection design for low-level radioactive waste disposal sites [J]. RADIATION PROTECTION, 2023, 43(S1): 99-105.
[2]	ZHAO Ri, LIU Zhaoxing, LIU Na, WANG Xianxiang, ZHANG Jing, LIANG Runcheng, LIU Xin, LINGHU Renjing, DAI Yuling. A new generation of human radiation dose calculation technology based on deformable mesh-type phantom [J]. RADIATION PROTECTION, 2023, 43(6): 533-541.
[3]	WANG Chuan, HE Junnan, SHEN Enwei. Understanding and thinking about the role of collective dose concept in radiation protection management of nuclear power plants [J]. RADIATION PROTECTION, 2023, 43(6): 598-602.
[4]	GOU Quanlu, WANG Caixia, ZHANG Jiannian, WAN Dengwei, YU Xiaodong, WANG Yilin. Design optimization and effect analysis for radiation protection in Haiyang nuclear power plant [J]. RADIATION PROTECTION, 2023, 43(6): 620-627.
[5]	GUO Chuangcheng, TANG Hui, QIU Jinmeng, WANG Chong, YANG Li, ZHANG Xin. Radiation protection design of nuclear air-cleaning units [J]. RADIATION PROTECTION, 2023, 43(6): 628-633.
[6]	ZHANG Xuan, LI Dehong, ZHANG Xiaole, HAO Guanghui, CAO Lei, ZHANG Jian, HUANG Jianwei, GUO Bin, ZHAO Rui, LI Mengfei. Research progress of testing methods for X-ray shielding performance of low-lead/lead-free materials [J]. RADIATION PROTECTION, 2023, 43(5): 412-421.
[7]	HUANG Yanjun, SHANGGUAN Zhihong, ZUO Weiwei. An investigation of the authorized release limits of radioactive effluent from nuclear power plant [J]. RADIATION PROTECTION, 2023, 43(5): 431-437.
[8]	WEI Yingjing, WU Zhifang, LIU Liye, LI Yin, WEI Shiliang, YAN Jun. Development of directional dose equivalent rate meter for emergency radiation protection [J]. RADIATION PROTECTION, 2023, 43(5): 467-472.
[9]	WANG Mengting, YANG Suyun, SHI Bingzi. Investigation on KAP of radiation protection among medical staff in nuclear medicine department and analysis of influencing factors [J]. RADIATION PROTECTION, 2023, 43(5): 501-509.
[10]	WU Renyao, GENG Changran, TIAN Feng, LIU Huan, TANG Xiaobin. Aircrew radiation dose assessment based on Monte Carlo simulation [J]. RADIATION PROTECTION, 2022, 42(5): 442-449.
[11]	BA Jun, XIN Kaiqiang, FAN Chong. Development of integrated radiation protection information perception and management and control platform for nuclear power plant [J]. RADIATION PROTECTION, 2022, 42(3): 236-243.
[12]	CAI Weichao, CAO Weihong. Research progress of reactive oxygen species and radiation-induced skin injury [J]. RADIATION PROTECTION, 2022, 42(2): 111-118.
[13]	MA Wencai, LIU Yanzhang, ZHAO Ying. Study on protection of workers from β-irradiation in the process of uranium purification and transformation [J]. RADIATION PROTECTION, 2021, 41(S1): 26-28.
[14]	LI Hui, ZANG Yikun, HU Yipeng. Analysis on radiation protection design of AP1000 unit of Sanmen nuclear power plant [J]. RADIATION PROTECTION, 2021, 41(1): 44-49.
[15]	LI Xianjie, ZHANG Zhe, HU Penghua, CHEN Gang, REN Jianjun. The development history of uranium mine ventilation in China [J]. RADIATION PROTECTION, 2021, 41(1): 9-16.