低剂量辐射线性无阈模型的适用性分析

Abstract

Abstract: For radiation protection purposes, it has been assume that the overall risk of radiation-induced cancer increases as a 1inear-nonthreshold function of the radiation dose. However, epidemiological evaluation cannot support and validate LNT model, and studies on biological effects of low dose radiation have found new results that are not conducive to the LNT model. The existing data do not exclude the existence of a threshold, and the dose-response relationship is known to vary, depending on the type of cancer, the dose, dose rate, and the LET of the radiation, the age, sex, and physiological state of the exposed individuals as well as other variables. On this basis, it is concluded that no alternative dose-response model for the carcinogenic effects of low-dose radiation is more plausible than the linear-non-threshold model, although other dose-response relationships cannot be excluded. Before the establishment of the new theory and new model, LNT model is still the most realistic attitude, and LNT is also the best methodology for radiation protection so far.

Key words: LNT, epidemiologic evaluation, low dose radiation, biological effect, dose-response relationship

CLC Number:

TL71

ZHENG Guofeng, SHANG Yuyao, XU Haifeng. Applicability analysis of linear non threshold model for low dose radiation[J].RADIATION PROTECTION, 2022, 42(6): 525-531.

References

[1] International Committee of Radiological Protection. Recommendations of the International Commission on Radiological Protection[R].ICRP Publication 9. ICRP, 1966.
[2] International Committee of Radiological Protection. Recommendations of the International Commission on Radiological Protection[R]. ICRP Publication 60. ICRP,1991.
[3] NCRP. Implications of recent epidemiologic studies for the linear non-threshold model[R]. Bethesda, MD: NCRP, Commentary 27, 2018.
[4] International Committee of Radiological Protection. The 2007 Recommendation of the International Commission on Radiological Protection[R]. ICRP Publication 103. ICRP, 2007.
[5] Ulsh, Brant A. A critical evaluation of the NCRP commentary 27 endorsement of the linear no-threshold model of radiation effects[J]. Environmental Research,2018,167472-487.
[6] 周永增. 辐射防护的生物学基础——辐射生物效应[J]. 辐射防护, 2003, 23(2):90-101.
ZHOU Yongzeng. Biological basis of radiation protection—Biological effects of radiation[J]. Radiation Rrotection, 2003, 23(2):90-101.
[7] 金晓东,李强. 低剂量辐射超敏感性研究进展[J]. 原子核物理评论, 2007, 24(3):228-233.
JIN Xiaodong, LI Qiang. Progress in low dose radiation related hyper-radiosensitivity[J]. Nuclear Physics Review, 2007,24(3):228-233.
[8] International Committee of Radiological Protection. Low dose extrapolation of radiation-related cancer risk[R].ICRP Publication 99. ICRP, 2006.
[9] Csaba, Gyorgy. Hormesis and immunity: a review[J]. Acta microbiologica et immunologica Hungarica: A quarterly of the Hungarian Academy of Sciences,2019,66(2):155-168.
[10] 魏新锋,王蕊,衣峻萱,等. 低剂量辐射生物效应的研究进展[J]. 中国辐射卫生,2022,31(1):113-118+128.
WEI Xinfeng, WANG Rui, YI Junxuan, et al. Research progress in biological effects of low-dose radiation[J]. Chinese Journal of Radiologial Health, 2022,31(1):113-118+128.
[11] Nickoloff J A, Sharma N, Allen C P, et al. Roles of homologous recombination in response to ionizing radiation-induced DNA damage[J]. Int J Radiat Biol, 2021: 1-12.
[12] 周平坤. 低剂量辐射效应及给辐射防护的启示[C] //2004全国医用辐射防护与安全学术研讨会论文汇编.北京:中华医学会, 2004:98-101.
[13] 陶丹,程晶. 低剂量辐射超敏感性分子机制的研究进展[J]. 肿瘤防治研究,2008,35(5):367-370.
TAO Dan, CHENG Jing. Advances in molecular mechanisms of low dose radiation hypersensitivity[J]. Cancer Prevention and Teatment Research, 2008,35(5):367-370.
[14] WANG Q, CHEN Y Y, CHANG H Y, et al. The role and mechanism of ATM-mediated autophagy in the transition from hyperradiosensitivity to induced radioresistance in lung cancer under low-dose radiation[J]. Front Cell Dev Biol, 2021, 9: 650819.
[15] Calabrese E J, From muller to mechanism: how LNT became the default model for cancer risk assessment[J]. Environ Pollut, 2028, (214):289-302.
[16] 闵锐. 辐射危害流行病学调查与医源性辐射危害评估[J]. 辐射研究与辐射工艺学报,2011,292:77-83.
MIN Rui. Epidemiologic research of radiation risk and risk evaluation of medical exposure[J]. Journal of Radiation Research and Radiation Technology, 2011, 292: 77-83.
[17] 周平坤. 核辐射对人体的生物学危害及医学防护基本原则[J]. 首都医科大学学报,2011,32(2):171-176.
ZHOU Pingkun. The detriment of nuclear radiation on human and the protection principal[J]. Journal of Capital Medical University, 2011,32(2):171-176.
[18] UNSCEAR. Sources and efects of ionizing radiation: Volume II: Efects[R]. UNSCEAR 2000 Report. New York, 2000.
[19] UNSCEAR. Sources and efects of ionizing radiation: Volume Ⅰ:Sources;Volume Ⅱ:Efects[R]. UNSCEAR 2008 Report. New York,2010.
[20] UNSCEAR. The Chernobyl accident. UNSCEAR's assessments of the radiation effects. (2012-07-16) [2013-08-12]. http://www.unscaer.org/unscaer/en/chernbyl.html.
[21] Tharmalingam, Sujeenthar, Sreetharan, et al. Re-evaluation of the linear no-threshold (LNT) model using new paradigms and modern molecular studies[J]. Chemico-biological Interactions,2019,30154-67.
[22] Costantini, David, Borremans, Benny. The linear no-threshold model is less realistic than threshold or hormesis-based models: An evolutionary perspective[J]. Chemico-biological Interactions,2019,30126-33.
[23] Vaiserman A M, Koliada A, Zabuga O, et al. Health impacts of low-dose ionizing radiation: Current scientific debates and regulatory issues[J]. Dose-response, 2018, 16(3):1-27.
[24] Kaushik N, Kim M J, Kim R K, et al. Low-dose radiation decreases tumor progression via the inhibition of the JAK1/STAT3 signaling axis in breast cancer cell lines[J]. Sci Rep, 2017,7:43361.
[25] 刘长安,杨光,贾廷珍. 低剂量辐射暴露人群的流行病学研究[J]. 中国肿瘤,2002,11(2):91-93.
[26] DeVita R,Oliver A,Spinelli A,et al. Health status and internal radio contamination assessment in children exposed to the fallout of the Chernobyl accident [J].Arch Environ Health, 2000,55(3):181-186.
[27] Upton A C. 低水平电离辐射致癌效应剂量响应关系的评论性再评估[J]. 辐射防护通讯,2003,23(2):1-5.
Upton A C. Critical reevaluation of the dose-response relationships for carcinogenic effects of low-level ionizing radiation[J]. Radiation Protection Bulletin, 2003,23(2):1-5.
[28] 陈如松. 辐射的低剂量生物效应及分子流行病学研究现状[J].辐射防护通讯,2003,23(1):13-19.
CHEN Rusong. Current study on the biological effects of low dose radiation and molecular epidemiology in radiation protection[J]. Radiation Protection Bulletin, 2003, 23(1): 13-19.
[29] UNSCEAR. Biological mechanisms of radiation actions at low doses[R]. United Nations, New York,2012.
[30] International Committee of Radiological Protection. Non-stochastic effects of ionising radiation[R]. ICRP Publication 41. ICRP, 1984.
[31] 谭承军,商照荣,上官志洪,等. 核电厂风险对比分析[J]. 核安全,2012,(4):56-62.
TAN Chengjun, SHANG Zhaorong, SHANGGUAN Zhihong, et al. Risk analysis on nuclear power plant[J]. Nuclear Safety, 2012,(4):56-62.
[32] Calabrese, Edward J, Golden, Robert J. Why toxicologists resisted and radiation geneticists supported EPA's adoption of LNT for cancer risk assessment[J]. Chemico-biological Interactions,2019,310Article 108736-1-Article 108736-4.

Applicability analysis of linear non threshold model for low dose radiation

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 3

Metrics

Comments

Recommended 10

[1]	HU Changkun, ZHANG Xuemei, MA Zenchun, GAO Yue. Effects of low dose radiation on intestinal injury in mice [J]. RADIATION PROTECTION, 2021, 41(4): 315-320.
[2]	XU Zhao, CHEN Ni, WANG Zhigang, LI Taosheng. Dose effect of high-energy neutron radiation on Caenorhabditis elegans [J]. RADIATION PROTECTION, 2019, 39(2): 150-156.
[3]	Zheng Junzheng. New progress in the field of radiological protection [J]. RADIATION PROTECTION, 2016, 36(6): 393-407.