电离辐射诱发癌症的线性无阈模型研究动态

Abstract

Abstract: The linear non threshold (LNT) model for cancer induced by ionizing radiation is the Foundation and basis of nuclear and radiation protection supervision. However, in recent years, the validity of LNT risk model has been questioned more and more. It is considered that the LNT based regulatory system has brought excessive cost to the society. In this paper, the recent international literature on LNT is studied to explore the development trend and further research direction of LNT, so as to provide reference for the domestic work in related fields.

Key words: radiation, the linear non threshold, challenge, research direction

CLC Number:

TL71

LIU Xiaoming, WU Xiaoyan, MA Yuefeng, ZHANG Yanna, XUE Xiangming, GU Xiaona, ZHAN Jingming, LIU Zhanqi, BIAN Linxiu. The research trends of linear non threshold hypothesis on cancer induced by ionizing radiation[J].RADIATION PROTECTION, 2022, 42(6): 518-524.

References

[1] Yanovskiy M,Shaki Y Y,Socol Y. Ethics of adoption and use of the linear no-threshold model[J]. Dose Response, 2019, 17(1): 1-3.
[2] National Research Council (NRC). Health risks from exposure to low levels of ionizing radiation: BEIR VII—Phase 2[M]. Washington DC: The National Academies Press, 2006: 424. ISBN: 0-309-53040-7 .
[3] Boice J D Jr. The linear non threshold (LNT) model as used in radiation protection: an NCRP update[J]. Int J Radiat Biol, 2017, 93(10):1079-1092.
[4] Costantini D,Borremans B.The linear no-threshold model is less realistic than threshold or hormesis based models: An evolutionary perspective[J]. Chem Biol Interact, 2019,301:26-33.
[5] Calabrese E J, Hanekamp J C, Shamoun D Y, et al. The EPA cancer risk assessment default model proposal: moving away from the LNT[J]. Dose Response, 2018, 16(3):1-4.
[6] Vaiserman A M. Radiation hormesis: historical perspective and implications for low-dose cancer risk assessment[J]. Dose Response, 2010, 8(2): 172-191.
[7] Seong K M, Seo S, Lee D, et al. Is the linear no-threshold dose-response paradigm still necessary for the assessment of health effects of low dose radiation?[J]. J Korean Med Sci,2016, 31: S10-23.
[8] Anonymous. Genetic effects of atomic radiation[J]. Science, 1956,123:1157-1164.
[9] NCRP. Implications of recent epidemiologic studies for the linear non-threshold model[R]. NCRP Commentary 27,Bethesda, MD: NCRP,2018.
[10] Ulsh B A. A critical evaluation of the NCRP commentary 27 endorsement of the linear no-threshold model of radiation effects[J].Environ Res, 2018,167:472-487.
[11] Socol Y. Reconsidering health consequences of the Chernobyl accident[J]. Dose Response, 2015,13(1):1-10.
[12] Socol Y, Dobrzynski L. Atomic bomb survivors life-span study: insufficient statistical power to select radiation carcinogenesis model[J]. Dose Response, 2015, 13(1): 1-17.
[13] Grant E J, Brenner A V, Sugiyama H, et al. Solid cancer incidence among the life span study of atomic bomb survivors: 1958—2009[J]. Radiation Research, 2017, 187(5): 513-537.
[14] Vaiserman A M, Koliada A, Zabuga O, et al. Health impacts of low-dose ionizing radiation: current scientific debates and regulatory issues[J]. Dose Response, 2018, 16(3):1-27.
[15] Sutou S. Black rain in Hiroshima: a critique to the Life Span Study of A-bomb survivors, basis of the linear no-threshold model[J]. Genes Environ, 2020,42:1-11.
[16] Siegel J A,Brooks A L,Fisher D R, et al. A critical assessment of the linear no-threshold hypothesis: its validity and applicability for use in risk assessment and radiation protection[J]. Clin Nucl Med, 2019,44(7):521-525.
[17] Men T, Brennan P, Boffetta P, et al. Russian mortality trends for 1991—2001: analysis by cause and region[J]. BMJ, 2003,327(7421):964.
[18] Ivanov V K. Late cancer and noncancer risks among Chernobyl emergency workers of Russia[J]. Health Phys,2007,93(5):470-479.
[19] Brenner D J, Doll R, Goodhead D T, et al. Cancer risks attributable to low doses of ionizing radiation: assessing what we really know[J]. Proc Natl Acad Sci U. S. A, 2003,100 (24) :13761-13766.
[20] Tharmalingam S,Sreetharan S,Brooks A L, et al. Re-evaluation of the linear no-threshold (LNT) model using new paradigms and modern molecular studies[J]. Chem Biol Interact, 2019, 301:54-67.
[21] Blimkie M S, Fung L C, Petoukhov E S, et al. Repair of DNA double-strand breaks is not modulated by low-dose gamma radiation in C57BL/6 mice[J]. Radiat Res, 2014,181 (5): 548-559.
[22] Park H S, Seong K M, Kim J Y, et al. Chronic low-dose radiation inhibits the cells death by cytotoxic high-dose radiation increasing the level of AKT and acinus proteins via NF-kappaB activation[J]. Int J Radiat Biol, 2013,89 (5): 371-377.
[23] Azzam E I, Raaphorst G P, Mitchel R E, et al. Radiation-induced adaptive response for protection against micronucleus formation and neoplastic transformation in C3H 10T1/2 mouse embryo cells[J]. Radiat Res, 1994,138 (Suppl 1) : S28-S31.
[24] Koturbash I, Merrifield M, Kovalchuk O. Fractionated exposure to low doses of ionizing radiation results in accumulation of DNA damage in mouse spleen tissue and activation of apoptosis in a p53/Atm-independent manner [J]. Int J Radiat Biol, 2017,93 (2): 148-155.
[25] Wong R S. Apoptosis in cancer: from pathogenesis to treatment[J]. Journal of Experimental & Clinical Cancer Research, 2011, 30(1): 87-87.
[26] Barazzuol L, Jeggo P A. In vivo sensitivity of the embryonic and adult neural stem cell compartments to low-dose radiation[J]. Journal of Radiation Research, 2016 ,57 (Suppl 1) :i2-i10.
[27] Laurent A, Blasi F. Differential DNA damage signalling and apoptotic threshold correlate with mouse epiblast-specific hypersensitivity to radiation[J]. Development, 2015, 142(21): 3675-3685.
[28] Rodriguesmoreira S, Moreno S G, Ghinatti G, et al. Low-dose irradiation promotes persistent oxidative stress and decreases self-renewal in hematopoietic stem cells[J]. Cell Reports, 2017, 20(13): 3199-3211.
[29] Sergeeva V A, Ershova E S, Veiko N N, et al. Low-dose ionizing radiation affects mesenchymal stem cells via extracellular oxidized cell-free DNA: a possible mediator of bystander effect and adaptive response [J]. Oxid Med Cell Longev, 2017,1-22.
[30] Alessio N, Gaudio S D, Capasso S, et al. Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process[J]. Oncotarget, 2015, 6(10): 8155-8166.
[31] Wang Z D, Wang J, Li Y, et al. Involvement of endoplasmic reticulum stress in apoptosis of testicular cells induced by low-dose radiation[J]. Journal of Huazhong University of Science and Technology-medical Sciences, 2013, 33(4): 551-558.
[32] Eom H S, Park H S, You G E, et al. Identification of cellular responses to low-dose radiation by the profiling of phosphorylated proteins in human B-lymphoblast IM-9 cells[J]. Int J Radiat Biol, 2017, 93 (11) : 1207-1216.
[33] Miller M L. A certified health physicist's reflections on a 40-year career in radiationprotection[J].Dose Response, 2016, 14(4):1-3.
[34] Graham J D. Comparing opportunities to reduce health risks:toxin control, medicine and injury prevention[R]. NCPA Policy Report No. 192. Dallas, TX: National Center for Policy Analysis;1995. http://www.ncpa.org/pdfs/st192.pdf. Updated July 1,1995.
[35] Genn Saji. 福岛核事故后未来疏散方向的安全分析报告——经验教训[A]. 第21界国际核工程大会论文集. 2013.
[36] Ketchum L E. Lessons of Chernobyl: SNM members try to decontaminate the world threatened by fallout[J]. J Nucl Med, 1987, 28(6):933-941.
[37] American Association of Physicists in Medicine. AAPM position statement on radiation risks from medical imaging procedures[S]. [PP 25-A 2011]. http://www.aapm.org/org/policies/detai ls.asp?id¼318&type¼PP. Updated April 10, 2018. AccessedAprial 30, 2020.
[38] Wei L C, Ding Y X, Liu Y H, et al. Low-dose radiation stimulates Wnt/beta-catenin signaling, neural stem cell proliferation and neurogenesis of the mouse hippocampus in vitro and in vivo[J].Curr Alzheimer Res,2012,9(3):278-289.
[39] Ring J, Tupin E, Elder D, et al. Health Physics Society Comments to U.S. environmental protection agency regulatory reform task force[J]. Health Phys, 2018,114(5):507-510.
[40] US Government Accountability Office. Low dose radiation: interagency collaboration on planning research could improve information on health effects[R]. Washington, DC: US GAO,2017:17-546.
[41] US Congress. HR 589—Department of Energy Research and Innovation Act [online]. 2018. Available at https://www.congress. gov/bill/115th-congress/house-bill/589. Accessed 16 April 2020.
[42] Boice J D, Ellis E D, Golden A P, et al. The past informs the future: An overview of the million worker study and the Mallinckrodt chemical works cohort[J]. Health Phys ,2018,114:381-385.
[43] John E Till , Harold L Beck, Helen A, et al. A review of dosimetry used in epidemiological studies considered to evaluate the linear nothreshold(LNT) dose-response model for radiation protection[J]. Int J Radiat Biol, 2017,93(10):1128-1144.
[44] National Council on Radiation Protection and Measurements. Health effects of low doses of radiation: perspectives on integrating radiation biology and epidemiology[R]. NCRP Commentary 24,Bethesda,MD: NCRP, 2015.
[45] Tharmalingam S, Sreetharan S, Brooks A L, et al. Re-evaluation of the linear no-threshold (LNT) model using new paradigms and modern molecular studies[J]. Chemico-Biological Interactions,2019,301:54-67.
[46] Abelquist E W. To mitigate the lnt model's unintended consequences-a proposed stopping point for as low as reasonably achievable[J]. Health Physics, 2019, 117(6): 592-597.
[47] Shamoun D Y. Linear No-Threshold model and standards for protection against radiation[J]. Regul Toxicol Pharmacol, 2016,77:49-53.
[48] Doss M. Future of radiation protection regulations[J]. Health Physics, 2016, 110(3): 274-275.
[49] Doss M. Linear no-threshold model vs. radiation hormesis[J]. Dose Response, 2013, 11(4): 480-497.
[50] Sacks B, Siegel J A. Preserving the anti-scientific linear no-threshold myth: authority, agnosticism, transparency, and the standard of care[J]. Dose Response, 2017, 15(3):1-4.

The research trends of linear non threshold hypothesis on cancer induced by ionizing radiation

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10

[1]	ZHENG Guofeng, SHANG Yuyao, XU Haifeng. Applicability analysis of linear non threshold model for low dose radiation [J]. RADIATION PROTECTION, 2022, 42(6): 525-531.
[2]	HE Ling, GAO Yiying, WANG Jie. Evaluation on implementation of diagnostic standards for common occupational radiation diseases by occupational disease diagnosis [J]. RADIATION PROTECTION, 2022, 42(6): 532-539.
[3]	MA Ya, HOU Dianjun, MAO Xuesong, LIU Wei, WANG Xiankai. Follow-up evaluation of diagnostic criteria for common radiation diseases ——Radiological health supervisors [J]. RADIATION PROTECTION, 2022, 42(6): 540-547.
[4]	TANG Hui, XU Bin, WANG Yan, DENG Xiaoqin, GU Hong. Development and application of automatic grasp and security linkage system for radioactive sources in urban radioactive waste repository in Sichuan province [J]. RADIATION PROTECTION, 2022, 42(6): 611-617.
[5]	HUANG Yanjun, SHANGGUAN Zhihong, XU Yueping, ZHANG Xiaofeng. A preliminary study on technical requirements for the design of environmental radiation monitoring program of marine nuclear power platform [J]. RADIATION PROTECTION, 2022, 42(5): 402-410.
[6]	LIN Minggui. The monitoring and assessment of atmospheric ¹⁴C specific activities around Ningde NPP [J]. RADIATION PROTECTION, 2022, 42(5): 418-424.
[7]	WU Renyao, GENG Changran, TIAN Feng, LIU Huan, TANG Xiaobin. Aircrew radiation dose assessment based on Monte Carlo simulation [J]. RADIATION PROTECTION, 2022, 42(5): 442-449.
[8]	CUI Hao, CHEN Peng, YANG Duanjie, LI Bing. Study on emergency management of near surface disposal facilities for radioactive waste [J]. RADIATION PROTECTION, 2022, 42(5): 467-472.
[9]	ZHUANG Dajie, GONG Daokun, LIAN Yiren, CHEN Lei, WANG Zhipeng, WANG Pengyi, SUN Shutang, SUN Hongchao, LI Guoqiang, ZHANG Jiangang. Analysis and evaluation of radiation level of the loaded and unloaded package of 3 m³ natural uranium hexafluoride for transport [J]. RADIATION PROTECTION, 2022, 42(4): 333-338.
[10]	HU Bo, LIU Wei, YANG Zhongtian. A preliminary study on the simultaneous effect of irradiation and heat on physicochemical properties and microstructure of bentonite [J]. RADIATION PROTECTION, 2022, 42(4): 345-353.
[11]	YUE Feng, QIAO Qingdang, GUO Cai, ZHU He, GUO Ruiping, GAO Jianwei, WANG Ruiying, LI Wenting. The nuclear submarine accident of former Soviet Union in 1985 and the evaluation of potential radiation impact on China [J]. RADIATION PROTECTION, 2022, 42(4): 361-367.
[12]	CHEN Faguo, LIN Haipeng, WANG Yong, DANG Xuhong, LIANG Runcheng, REN Yue. Development of single-cell single-particle microbeam and applications in radiobology [J]. RADIATION PROTECTION, 2022, 42(3): 184-192.
[13]	XU Yao, CHEN Xiaolei, HUANG Guangwei, WU Yunhui, CHEN Lin. Research on radiation dose field reconstruction method based on monitoring data from Fukushima nuclear accident [J]. RADIATION PROTECTION, 2022, 42(3): 193-200.
[14]	ZHANG Baozeng, DU Xichen, MA Xiao. Measurement and evaluation of electromagnetic radiation of 5G mobile communication base station [J]. RADIATION PROTECTION, 2022, 42(3): 222-228.
[15]	DAI Yongzhi, XIA Houqiong, CAO Jinjia, XIAO Hailiang, CHEN Qiang, LI Fang. The effect of ⁶⁰Co γ irradiation on the electrostatic adsorption efficiency of protection masks [J]. RADIATION PROTECTION, 2022, 42(3): 229-235.