间充质干细胞(MSC)在辐射损伤救治方面的研究进展

Abstract

Abstract: The probability of radiation incidences is increasing with the widespread use of nuclear energy in the field of military and civilian. Radiation exposures result in a variety of tissue injuries, including hematopoietic and immune system, gastrointestinal tract, lung and skin etc. Current treatment strategies had a dissatisfactory efficacy on victims who received lethal radiation dosis. Mesenchymal stem cells (MSCs) are low immunogenicity and suit for allogeneic application. MSCs have the capacity to differentiate a variety of cells and unique immunomodulatory effect and hematopoietic supporting capacity. MSCs can enhance hematopoietic reconstitution and tissue repair after irradiation through their differentiation capacity and paracrine effects. Herein, the recent research progress about the effect of MSCs on radiation injuries is systematically reviewed.

Key words: radiation injury, mesenchymal stem cells, hematopoietic reconstitution, tissue repair, extracellular vesicles

CLC Number:

R818

WANG Li, MA Dexun, Zhang Rui, ZHANG Chao, GAO Rui, LIU Shufeng. Research progress of mesenchymal stem cell for treatment of radiation injuries[J].RADIATION PROTECTION, 2020, 40(3): 250-255.

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Research progress of mesenchymal stem cell for treatment of radiation injuries

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