Abstract: In order to explore the changes of MXR7 genes expression in human liver cells HL-7702 and peripheral blood induced by radiation,the expression changes of MXR7 gene in human liver cells irradiated by ⁶⁰Co γ-ray were detected by real-time fluorescent quantitative PCR. Furthermore, MXR7 gene expression levels were detected in peripheral blood from radiation workers. Results showed that ionizing radiation can induce the change of MXR7 genes expression in human liver cells, and it is dose-related. The expression of MXR7 gene in peripheral blood from radiation workers was up-regulated to compare with the expression of non-radiation workers.

Key words: human liver cell HL-7702, radiation workers, MXR7 gene, ionizing radiation, peripheral blood