Abstract: To investigate the protective effects of C₆₀(OH)₂₄-SLN-E on mice exposed to sub-lethal doses of ⁶⁰Co γ radiation. SPF ICR mice (male) were given C₆₀(OH)₂₄-SLN-E intraperitoneally (i.p.) continuously for 7 days before whole-body ⁶⁰Co γ radiation. The total doses were 6.0 Gy and the dose rate was 0.42 Gy/min. The survival situation, the change of body weight and peripheral blood cell on the 14^th day after sub-lethal doses of ⁶⁰Co γ irradiation were observed. C₆₀(OH)₂₄-SLN-E pretreated before IR could effectively reduce the decrease of body weight and peripheral blood leukocyte in mice induced by ⁶⁰Co γ radiation, it could also enhance the recovery of hematopoiesis of red bone marrow after irradiation, which had statistical significance compared with the irradiation group (p<0.05). C₆₀(OH)₂₄-SLN-E has efficient capacity of radioprotection in mice exposed to sub-lethal doses of ⁶⁰Co γ radiation.

Key words: nucleus targeting, fullerol, solid lipid nanoparticles, ⁶⁰Co γ ray, radioprotective