富勒烯衍生物对X射线所致小鼠肝线粒体损伤的保护作用

Abstract

Abstract: To investigate whether fullerenes derivatives have protective effect to acute liver injury,we irradiated the Kunming mice with different doses of X-rays(12, 20, 40, 80 Gy),and injected fullerene derivative (CB) before or after irradiation. Experimental results show that the radiation can strongly induce free radical and damage to mitochondria, such as: to swell mitochondria, to produce lipid peroxidation and malondialdehyde (MDA). Chelating agent can significantly reduce the swelling of mitochondria and the formation of MDA, so as to maintain the structure integrity and function of mitochondria.

Key words: fullerene derivatives, mitochondria, X-ray, free radical

CLC Number:

X591

Chen Qiping, He Jiaheng, Ma Zongping, Wang Ganquan, Liu Guoping. Protective effect of fullerene derivatives against mitochondria damage in rat liver induced by X-ray[J].RADIATION PROTECTION, 2015, 35(4): 214-220.

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Protective effect of fullerene derivatives against mitochondria damage in rat liver induced by X-ray

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