The success of the lunar probe Chang’E-1 is the third milestone in the history of china’s space industry. Information technology is widely used in the process of the management, design,manufacture and test of the probe Change’E-1, which plays a very important role for the efficient and high-quality accomplishment of the probe Chang’E-1. The primary characteristics of Chang’E-1 are summarized in this paper, and the application and benefits of information technology for the development of Chang’E-1 are reviewed. The application of information technology in on-board facility, mainly in GNC system, is expounded in detail. In the end, the application of information technology in the course of flight control is introduced.