氚水致癌、致突变和致畸效应研究进展

Abstract

Abstract: With the wide application of tritiumand the increase of tritium concentration in environment, the biological effects caused by it have gradually attracted people's attention. As one of the isotopes of hydrogen, tritium can participate in many cycles of the biosphere, therefore environmental concentrations of tritium may cause damage to human and their offsprings. As a review of research progress on the biological effects of tritiatedwater, the carcinogenic, teratogenic and mutagenesis effects is highlighted therein.

Key words: Tritium, Environment, Biological effects

CLC Number:

Q345+.1

Li Shengri, Cui Fengmei, Liu Yulong, Tu Yu. Advances in Research on Carcinogenic, Mutagenic and Teratogenic Effects of Tritiated Water[J].RADIATION PROTECTION BULLETIN, 2019, 39(5): 32-35.

References

[1] Eyrolle F, Ducros L, Le Dizès S, et al. An updated review on tritium in the environment[J]. Journal of Environmental Radioactivity, 2018,181:128-137.
[2] Gao W, Lu H, Dong J, et al. Postnatal growth, neurobehavioral and neurophysiologic changes of prenatal low-dose β-radiation from tritiated water in mice[J]. Neurotoxicology and Teratology, 2002,24(2):247-254.
[3] Umata T, Kunugita N, Norimura T. A comparison of the mutagenic and apoptotic effects of tritiated water and acute or chronic caesium-137 gamma exposure on spleen T lymphocytes on normal and p53-deficient mice[J]. International Journal of Radiation Biology, 2010,85(12):1082-1088.
[4] Jha A N, Dogra Y, Turner A, et al. Impact of low doses of tritium on the marine mussel, Mytilus edulis: Genotoxic effects and tissue-specific bioconcentration[J]. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2005,586(1):47-57.
[5] Selivanova M A, Mogilnaya O A, Badun G A, et al. Effect of tritium on luminous marine bacteria and enzyme reactions[J]. Journal of Environmental Radioactivity, 2013,120:19-25.
[6] 邓冰, 井婧, 全旖, 等. 低剂量氚水对人体外周血淋巴细胞的影响[J]. 中国辐射卫生, 2016,25(1):6-10.
[7] 周湘艳, 高卫民, 王冰, 等. 低剂量氚水对发育中鼠中枢神经系统的影响及其机理研究[J]. 中华医学杂志, 1999,79(7):12-15.
[8] 高卫民, 周湘艳, 何湘平, 等. 出生前氚水照射对仔鼠海马神经元电生理及神经行为的影响[J]. 辐射防护, 1997,17(5):363-372.
[9] 张钦, 杜林, 马兆伟, 等. 秦山核电基地周围草地中不同形态氚的分布研究[J]. 核技术, 2018,41(12):76-81.
[10] 秦来来, 夏正海, 谷韶中, 等. 核设施周围大气中多形态氚的测量[J]. 核技术, 2018,41(10):79-85.
[11] Seyama T, Yamamoto O, Kinomura A, et al. Carcinogenic effects of tritiated water (HTO) in mice: in comparison to those of neutrons and gamma-rays[J]. Journal of Radiation Research, 1991,32(6):132-142.
[12] Yin H, Bhattacharjee D, Roy G, et al. Tumorigenesis in infant C3H/HeN mice exposed to tritiated water (HTO)[J]. Journal of Radiation Research, 2002,43(4):345-351.
[13] Revina V S, Voronin V S, Lemberg V K, et al. Comparative evaluation of the carcinogenic effects of chronic exposure to tritium oxide and external gamma-radiation[J]. Radiobiologiia, 1984,24(5):697-700.
[14] Hagger J A, Atienzar F A, Jha A N. Genotoxic, cytotoxic, developmental and survival effects of tritiated water in the early life stages of the marine mollusc, Mytilus edulis[J]. Aquatic Toxicology, 2005,74(3):205-217.
[15] Natarajan A T, Darroudi F, Jha A N, et al. Ionizing radiation induced DNA lesions which lead to chromosomal aberrations[J]. Mutation Research, 1993,299(3-4):297-303.
[16] Straume T, Carsten A L. Tritium radiobiology and relative biological effectiveness[J]. Health Physics, 1993,65(6):657-672.
[17] 崔凤梅, 胡明江, 包广粮, 等. 氚水的内照射损伤实验研究[J]. 辐射研究与辐射工艺学报, 2009,27(05):317-320.
[18] 郭丰莉, 王金山, 汪寿芳, 等. 氚水对大鼠的致突效应的研究[J]. 癌变·畸变·突变, 1990,(04):68-70.
[19] 高卫民, 周湘艳. 出生前氚水照射对仔代大鼠生长发育及神经行为的影响[J]. 中华放射医学与防护杂志, 1998,18(06):18-22.
[20] 姚晓波, 王永生, 邱俊, 等. 氚宫内照射对大鼠神经细胞分布及脑机能的影响[J]. 安徽医科大学学报, 2014,49(10):1371-1375.

Advances in Research on Carcinogenic, Mutagenic and Teratogenic Effects of Tritiated Water

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 4

Metrics

Comments

Recommended 10

[1]	Wang Bing, Lyu Huimin, Liu Yulong, Gao Weimin, Wang Chunyan, Dong Jinchan, Zhang Wei, Chen Weibo. Effects of Low-dose Tritium Irradiation onthe Central Nervous System of Offspring Rats and Its Mechanism [J]. RADIATION PROTECTION BULLETIN, 2019, 39(5): 2-18.
[2]	Lyu Huimin, Zhou Xiangyan, Li Li, Zhang Wei, Liu Yulong, Chen Weibo. Distribution, Metabolism Transfer and Dose Estimation for Tritiated Water in Rats and Mice [J]. RADIATION PROTECTION BULLETIN, 2019, 39(5): 19-25.
[3]	Quan Yi, Deng Bing, Zhou Caijie, Tan Zhaoyi. Research Progress on Cell Damage Induced by Low Dose Tritium Irradiation [J]. RADIATION PROTECTION BULLETIN, 2019, 39(5): 26-31.
[4]	Zhou Yunzhu, Song Yu. Research Progress of Traditional Chinese Medicine Preparations’ Effect on Decorporation of Tritiated WaterResearch Progress on Decorporation of Tritiated Water by Traditional Chinese Medicine Preparation [J]. RADIATION PROTECTION BULLETIN, 2019, 39(5): 42-44.