辐射防护剂的研究进展

Abstract

Abstract: The structure and function of cells and tissues of the human body may change after exposure to a certain dose of radiation. The main mechanism is that, after the ionization produces a large number of free radicals, the DNA and telomerase in the cell are destroyed, the mitochondrial membrane potential homeostasis is destroyed, and the apoptosis, abnormal proliferation and function change of the cell are then resulted. The existing radiation protective agents and natural drugs are reviewed briefly, and the possible mechanisms are discussed. N-acetylcysteine is the main component of hydrogen thiol radiation protective agent. Vitamins mainly include vitamin E and vitamin C. There are many kinds of plant polysaccharides with radiation protection effect. Immune modulators and granulocyte colony factor in cytokines have good radiation protection effect. A natural ingredient of Chinese medicine, 14-deoxydioxy-11, 12-dihydrographolide, as a new anti-radiation drug, is worth further study for its mechanism of action.

Key words: Radiation protective agents, Oxygen free radicals, Radiation resistance, Ionization radiation

CLC Number:

R979.6

Liu Xiaoqiang, Zhang Xijin, Ma Dexun, Liu Shufeng. Recent Advances in Radiation Protective Agent Research[J].RADIATION PROTECTION BULLETIN, 2019, 39(6): 1-5.

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Recent Advances in Radiation Protective Agent Research

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