60Co γ射线8.0 Gy剂量诱导小鼠十二指肠恢复期损伤

Abstract

Abstract: Gamma irradiation was given one-timewith a dose of 8.0 Gy from ⁶⁰Co in mice peritoneal. On the 15th day after irradiation, the duodenum were taken out to observe the pathological changesand analyze the expression level of BCL-2 and TGF-β. The results show that:1)Compared with controls, the duodenum pathology of radiation group appear villiartophy, shorter or fall-off. For severe cases, intestinal mucosa epithelium extensive necrosis and desquamation is observed. 2) BCL-2 expression level drops, and TGF-β expression level rises, in radiation group. The experiment provesthat under the radiation situation, the duodenum radiation injury still exists in recovery phase.

Key words: Radioactive Duodenitis, Mice, Recovery phase

CLC Number:

TL818

Ren Yue, Dong Juancong, Zhang Zhongxin, Yuan Yayi, Wang Chao, Zuo Yahui, Li Youchen. The Duodenum Injury of Mice in Recovery Phase Induced by 8.0 Gy γ-Irradiation of ⁶⁰Co[J].RADIATION PROTECTION BULLETIN, 2016, 36(3): 38-41.

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The Duodenum Injury of Mice in Recovery Phase Induced by 8.0 Gy γ-Irradiation of ⁶⁰Co

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The Duodenum Injury of Mice in Recovery Phase Induced by 8.0 Gy γ-Irradiation of 60Co

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The Duodenum Injury of Mice in Recovery Phase Induced by 8.0 Gy γ-Irradiation of ⁶⁰Co