Abstract: To explore the treatment technique of such radiation injuries as in a major radiological accident in which a victim suffered mild bone marrow radiation sickness combined wiht heavy acute radiation induced skin injury, based on his dose estimation, clinical manifestations and disease treatments. History inquiry in detail, earlier physical dose estimation and biological dose estimation were conducted in conjunction with analyzing the chromosome aberration of peripheral blood lymphocytes. The physical dose was estimated by Monte Carlo method. The systematic laboratory and imaging examination was performed to evaluate the condition.The comprehensive analysis was conducted to determine the diagnosis and treatment plan. During the treatment of patients with radiation injury, we should pay attention to the combination of physiology and psychology. Local application of autologous SVF transplantation and skin transplantation can achieve good results in radioactive skin injuries.

Key words: ¹⁹²Ir, radiation skin injury, medical management, dose estimation