细胞衰老在放射损伤发生发展中的研究进展

摘要/Abstract

摘要： 放射损伤是肿瘤患者放射治疗的常见并发症,其发生率高,防治困难,严重影响患者的生活质量。细胞衰老是一种细胞周期停滞的状态,放射治疗通常会促使受照射细胞进入衰老状态,这有利于体内肿瘤细胞的清除,同时也对正常细胞产生伤害。随着研究的不断深入,电离辐射诱导的细胞衰老在放射损伤中发挥的作用越来越受到重视,本文对细胞衰老在放射损伤中的研究进展进行综述。

关键词: 细胞衰老, 电离辐射, 放射损伤

Abstract: Radiation injury is a common complication of radiotherapy for cancer patients. Radiation injury has a relative high incidence and is difficult to prevent and to be treated, which may seriously affects the life quality of patients. Cell senescence is a state in which the cell cycle is stagnated, and radiation therapy usually makes cells enter a state of senescence, which facilitates the removal of tumor cells in the body while may also causing damage to normal cells. With the progress of research, the role of ionizing radiation-induced cell senescence in radiation injury has received more and more attention, and the research progress of cell senescence in radiation injury is reviewed in this paper.

Key words: cell senescence, ionizing radiation, radiation injury

中图分类号:

R818

牛晓凤, 杨思瑜, 邓丽娟, 任钲, 毕承柳, 杨军. 细胞衰老在放射损伤发生发展中的研究进展[J]. 辐射防护通讯, 2024, 44(6): 1-9.

NIU Xiaofeng, YANG Siyu, DENG Lijuan, REN Zheng, BI Chengliu, YANG Jun. Research progress of cell senescence in the occurrence and development of radiation injury[J]. RADIATION PROTECTION BULLETIN, 2024, 44(6): 1-9.

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