TGF-β1对放射性肺纤维化作用的研究进展

Abstract

Abstract: Transforming growth factor-β1 (TGF-β1) mediates complex fibrotic signaling pathways during the development of pulmonary fibrosis. Especially in the repair of lung tissue injury, TGF-β1, as an important cell growth factor plays an important role, can activate fibroblasts and promote matrix synthesis, resulting in a large number of collagen. Radiation induced lung injury is a common complication in radiotherapy of lung disease. Early manifestations are radioactive pneumonia and advanced manifestations are radioactive pulmonary fibrosis. Understanding of the molecular mechanism of TGF-β1 in the pathogenesis and progression of pulmonary fibrosis is of great significance to prevent, treat pulmonary fibrosis and reduce the incidence of complications. In this paper, the molecular mechanism of TGF-β1 in the role of radiation pulmonary fibrosis and treatment progress were reviewed.

Key words: TGF-β1, radioactive pulmonary fibrosis, molecular mechanism

CLC Number:

R811.5

CHEN Zhiyuan, DONG Zhuo, WEI Wei, LU Yahui, WANG Rui, YUAN Mingcheng, JIN Shunzi. Research progress of TGF-β1 on radiation-induced pulmonary fibrosis[J].RADIATION PROTECTION, 2018, 38(2): 171-176.

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Research progress of TGF-β1 on radiation-induced pulmonary fibrosis

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