质子闪光放射治疗中子剂量分析

Abstract

Abstract: The distribution of secondary neutrons in the water model under the condition of ultra-high dose rate proton beam (FLASH ) is calculated by Monte Carlo method. The calculation results show that the distribution of neutrons produced by the indoor energy degrader in the water phantom can reach ten times of that without the degrader when the proton energy is from 70 to 116 MeV. In the case of low proton energy, the cumulative neutron dose of one treatment can reach more than 200 mGy.

Key words: proton therapy, neutrons dose, Monte Carlo, energy reducer, FLASH

CLC Number:

TL72

LI Kundong, ZHANG Haiyang, JIA Meichao, XIAO Jie. Analysis on neutron dose at proton FLASH therapy room[J].RADIATION PROTECTION, 2025, 45(3): 285-291.

References

[1] van de Schoot A J A J, de Boer P, Crama K F, et al. Dosimetric advantages of proton therapy compared with photon therapy using an adaptive strategy in cervical cancer[J]. Acta Oncologica, 2016, 55(7): 892-899.
[2] Bezak E, Takam R, Yeoh E, et al. The risk of second primary cancers due to peripheral photon and neutron doses received during prostate cancer external beam radiation therapy[J]. International Journal Devoted to the Applications of Physics to Medicine and Biology, 2017, 42: 253-258.
[3] Schneider U, Agosteo S, Pedroni E, et al. Secondary neutron dose during proton therapy using spot scanning[J]. International Journal of Radiation Oncology, Biology, Physics, 2002, 53(1): 244-251.
[4] Trinkl S, Mares V, Englbrecht F S, et al. Systematic out-of-field secondary neutron spectrometry and dosimetry in pencil beam scanning proton therapy[J]. Medical Physics, 2017, 44(5): 1912-1920.
[5] WANG Jinlong, Cruz L A, WU Qingbiao, et al. Radiation shielding design of a compact single-room proton therapy based on synchrotron[J]. Nuclear Science and Techniques, 2020, 31(1): 1.
[6] Tatari N. Neutron production in the scattering S250 mevion proton-therapy system[DB/OL].[2024-04-13]. https://arxiv.org/pdf/2210.12602.
[7] Cunningham S, McCauley S, Vairamani K, et al. FLASH proton pencil beam scanning irradiation minimizes radiation-induced leg contracture and skin toxicity in mice[J]. Cancers, 2021, 13(5): 1012.
[8] LIANG Z, CHEN W, QIN B, et al. Design of the energy selection system for proton therapy based on GEANT4[C]//Proceedings of Cyclotrons 2016. Zurich: JACoW, 2016: 30-32.
[9] LIN Shixiong, Boehringer T, Coray A, et al. More than 10 years experience of beam monitoring with the Gantry 1 spot scanning proton therapy facility at PSI[J]. Medical Physics, 2009, 36(11): 5331-5340.
[10] Schippers J M. Beam transport systems for particle therapy[DB/OL].[2024-04-13]. https://arxiv.org/abs/1804.08551.
[11] Grassberger C, Dowdell S, Lomax A, et al. Motion interplay as a function of patient parameters and spot size in spot scanning proton therapy for lung cancer[J]. International Journal of Radiation Oncology Biology Physics, 2013, 86(2): 380-386.
[12] Tatsuhiko S, Yosuke I, Shintaro H, et al. Recent improvements of the particle and heavy ion transport code system–PHITS version 3.33[J]. Journal of Nuclear Science and Technology, 2024, 61(1): 127-135.
[13] 汪金龙, Cruz L A, 刘铮铮, 等. 权重适配的布拉格峰展宽方法[J]. 中国医学物理学杂志, 2019, 36(1): 50-54.
WANG Jinlong, Cruz L A, LIU Zhengzheng, et al. Weight adaption-based spread-out Bragg peak method[J]. Chinese Journal of Medical Physics, 2019, 36(1): 50-54.
[14] ICRU. ICRU Report 49: Stopping power and ranges for protons and alpha particles[R/OL].[2024-04-13]. https://www.icru.org/report/stopping-power-and-ranges-for-protons-and-alpha-particles-report-49/.
[15] Paganetti H, Niemierko A, Ancukiewicz M, et al. Relative biological effectiveness (RBE) values for proton beam therapy[J]. International Journal of Radiation Oncology Biology Physics, 2002, 53(2): 407-421.
[16] Baiocco G, Barbieri S, Babini G. et al. The origin of neutron biological effectiveness as a function of energy[J]. Scientific Reports, 2016,6(1): 34033.
[17] Rana S, Greco K, Samuel E J J, et al. Radiobiological and dosimetric impact of RayStation pencil beam and Monte Carlo algorithms on intensity-modulated proton therapy breast cancer plans[J]. Journal of Applied Clinical Medical Physics, 2019, 20(8): 36-46.
[18] Gottumukkala R V, Kalra M K, Tabari A, et al. Advanced CT techniques for decreasing radiation dose, reducing sedation requirements, and optimizing image quality in children[J]. RadioGraphics, 2019, 39(3): 709-726.
[19] Kai M, Homma T, Lochard J, et al. ICRP Publication 146: Radiological protection of people and the environment in the event of a large nuclear accident: update of ICRP publications 109 and 111[J]. Annals of the ICRP, 2020, 49(4): 11-135.
[20] Hall E J. Lessons we have learned from our children: cancer risks from diagnostic radiology[J]. Pediatric Radiology, 2002, 32(10): 700-706.
[21] ICRP.The 2007 recommendations of the international commission on radiological protection[R]. ICRP Publication 103. Amsterdam: Elsevier, 2007.

Analysis on neutron dose at proton FLASH therapy room

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