纳米氧化铋软膏对放射性皮肤损伤的防护作用

Abstract

Abstract: To protect the skin of interventional therapy operators from radioactive damage, a bismuth oxide nano ointment has been developed. Various proportion of bismuth oxide cream were prepared, through rats model to assess the protetion effect against acute radiation skin injury induced by 40 Gy X-ray exposure. Then the mice exposed to 4 Gy γ-ray TBI induced the hemopoietic system stress, and the prevention effects of the various proportion bismuth oxide creams were analyzed by WBC counts, PLT counts and bone marrow nucleated cells counts. And the radionuclide ¹²⁵I was administrated i.v.to the mice and SPECT scan was performed. The shield efficiency of internal exposure was accessed between the bismuth oxide cream group and vehicle. The prevention of the bismuth oxide cream was observed by application on the skin of rats prior to the 40 Gy X-ray exposure. Various proportion bismuth oxide cream presented significant prevention effects on the hemopoietic system stress induced by 4 Gy gamma-ray TBI. The bismuth oxide cream applied on the skin of mouse effectively blocked the gamma photon generated by ¹²⁵I.

Key words: nano-bismuth oxide, radiation protection, radiodermatitis, cream

CLC Number:

R818.05

ZHOU Xiaoliang, YANG Yuwei, LIU Jinjian, TANG Haikang, XU Wenqing. Protection effects of a nano-bismuth oxide cream against skin injury induced by radiation[J].RADIATION PROTECTION, 2024, 44(6): 711-717.

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Protection effects of a nano-bismuth oxide cream against skin injury induced by radiation

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