Abstract: In order to improve the accuracy of spatial direction measuring instrument, and to meet the requirement of extremely high measurement accuracy, the influence of image sensor’s pixel displacement on centroiding accuracy is not negligible. The laser interferometry is a major method for measuring pixel displacement in current. The causes and effects of image sensor’s pixel displacement are described in this paper. The techniques of laser interferometry for measuring pixel displacement are introduced and analyzed. The key issues, difficulties and future development trends of the technique for pixel displacement measurement are summarized.