干细胞规模化扩增技术在核应急医学救援中的应用策略

Abstract

Abstract: With the widespread global application of nuclear energy and rising geopolitical risks, the potential threat of nuclear and radiological emergencies (NRE) persists. Nuclear radiation exposure can lead to multi-organ and multi-system damage, and traditional symptomatic supportive care and treatment are limited. Stem cells provide revolutionary therapeutic potential for nuclear emergency medical rescue by virtue of their multiple biological functions such as tissue repair, immune regulation and hematopoietic reconstruction. This paper intends to explore the application strategy of stem cell scale expansion technology in nuclear emergency medical rescue.

Key words: nuclear emergency medical rescue, stem cells, large-scale amplification technology, application strategy

CLC Number:

R818

YANG Chao, LIU Minghao, ZHU Lei, BAI Fan, CHEN Shuangjing, GUO Shanshan, WANG Jianan. Application strategy of stem cell scale expansion technology in nuclear emergencymedical rescue[J].RADIATION PROTECTION BULLETIN, 2026, 46(2): 39-43.

References

[1] Streffer C, Hande M P. Effects of ionizing radiation exposure in offspring and next generations[J]. International Journal of Radiation Biology, 2024, 100(9): 1 237-1 239.
[2] Davies L C, Biard L, García-Olmo D, et al. Defining minimal criteria for peer-reviewed reporting of mesenchymal stromal cell clinical trials for autoimmune diseases[J]. Cytotherapy, 2025, 27(11): 1 326-1 337.
[3] Lee O J, Keating A. Mesenchymal stromal cells: an update[J]. Current Opinion in Hematology, 2025, 32(5): 270-278.
[4] Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement[J]. Cytotherapy, 2006, 8(4): 315-317.
[5] XU Hui, ZHANG Jinwang, ZHANG Hexiao, et al. The inhibitory impact of various total body irradiation doses on the hematopoietic system of mice[J]. Blood science, 2024, 7(1): e00214.
[6] Lmamura M, Shigematsu A. Perspectives on the use of a medium-dose etoposide, cyclophosphamide, and total body irradiation conditioning regimen in allogeneic hematopoietic stem cell transplantation: the Japanese experience from 1993 to present[J]. Journal of Clinical Medicine, 2019, 8(5): 569.
[7] GAO Dandan, ZHANG Heng, SUN Wanjun, et al. Radiation-induced intestinal injury: molecular mechanisms and therapeutic status[J]. DNA and Cell Biology, 2024, 43(11): 537-548.
[8] LUO Yujun, WANG Beibei, LIU Jianhua, et al. Ginsenoside RG1 enhances the paracrine effects of bone marrow-derived mesenchymal stem cells on radiation induced intestinal injury[J]. Aging, 2020, 13(1): 1 132-1 152.
[9] YANG Leilei, FANG Chengfeng, SONG Caifang, et al. Mesenchymal stem cell-derived exosomes are effective for radiation enteritis and essential for the proliferation and differentiation of Lgr5⁺ intestinal epithelial stem cells by regulating Mir-195/Akt/β-Catenin pathway[J]. Tissue Engineering and Regenerative Medicine, 2023, 20(5): 739-751.
[10] Arroyo-Hernández M, Maldonado F, Lozano-Ruiz F, et al. Radiation-induced lung injury: current evidence[J]. BMC Pulmonary Medicine, 2021, 21(1): 9.
[11] WANG Hongyu, WANG Jinbao, YANG Gaosheng, et al. Human umbilical cord mesenchymal stem cell-derived exosomes mitigate acute radiation-induced intestinal oxidative damage via the Nrf2/HO-1/NQO1 signaling pathway[J]. PLoS One, 2025, 20(6): e0324238.

Application strategy of stem cell scale expansion technology in nuclear emergencymedical rescue

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