Abstract: Wound contamination by radionuclide is a common scenario in nuclear and radiation accidents, and its medical management constitutes a crucial aspect of nuclear emergency medical rescue. Radionuclide wound contamination can cause various hazards such as internal radiation injury, risk of stochastic effects, chemical toxicity, wound healing disorders, contamination spread and transfer, and increased psychological burden. The US National Council on Radiation Protection and Measurements(NCRP), in collaboration with the International Commission on Radiological Protection(ICRP), has developed a biokinetic model for wounds contaminated with radionuclides. This model categorizes the radionuclides at the wound site into five states based on their physicochemical properties and summarizes the dynamic laws of retention, absorption, accumulation, and excretion of soluble and insoluble nuclides in the wound. In light of the actual application scenarios of nuclear emergency medical rescue, this paper further sorts out the guiding significance of the above-mentioned biokinetic model in the rescue practice for early medical treatment decisions and decorporation therapy, etc., hoping to provide some reference for colleagues engaged in nuclear emergency medical rescue.

Key words: radionuclide-contaminated wounds, biokinetic model, medical rescue of nuclear emergency, soluble nuclides, insoluble nuclides, decorporation therapy