12C离子照射对MDM2和GADD45A基因表达的影响

Abstract

Abstract: To study the effect of heavyion on expression of MDM2 and GADD45A in human lymphocyte cell. Gene expression was expression of MDM2 and GADD45A exposure to heavyion at different time was measured byreal-time quantitative PCR. Expression of MDM2 and GADD45A was at different times, furthermore, showed up regulation in human lymphocyte cell irradiated by heavy ion at 12 hours later. MDM2 and GADD45A can be induced by heavyions at 12 hours later and may play an important role in apoptosis.

Key words: Gene Expression, Apoptosis, Heavyion

CLC Number:

Q691

Liu Jiangong, Liu Hongyan, Dang Xuhong, Zhang Zhongxin, Zhang Huifang, Duan Zhikai, Zuo Yahui. Gene Expression of Human Lymphocyte Cells Following Heavyion Irradiations[J].RADIATION PROTECTION BULLETIN, 2014, 34(2): 32-34.

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Gene Expression of Human Lymphocyte Cells Following Heavyion Irradiations

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