亚低温对急性辐射损伤小鼠保护效果

辐射防护通讯 ›› 2014, Vol. 34 ›› Issue (3): 12-15.

亚低温对急性辐射损伤小鼠保护效果

李曙芳, 岳娟, 黄立群, 王永丽, 安全, 李幼忱, 周晋源

中国辐射防护研究院, 太原, 030006

收稿日期:2014-03-01 出版日期:2014-06-20 发布日期:2025-02-26
通讯作者: 安全,anquan@cirp.org.cn
作者简介:李曙芳(1983- ),女,2009年毕业于山西医科大学卫生毒理学专业,硕士; 助理研究员。
基金资助:
山西省实验动物专项[2013(k07)]; 中国核工业集团公司基金资助项目(JJ13010201)。

Effects of Mild Hypothermia on Acute Radiation Syndrome in Mice

Li Shufang, Yue Juan, Huang Liqun, Wang Yongli, An Quan, Li Youchen, Zhou Jinyuan

China Institute for Radiation Protection, Taiyuan, 030006

Received:2014-03-01 Online:2014-06-20 Published:2025-02-26

摘要/Abstract

摘要： 目的探讨亚低温干预对急性辐射损伤小鼠的保护效果。方法 40只雄性BALB/c小鼠随机分为4组,受照组均接受6 Gyγ射线单次全身照射,(亚低温+照射)组在照射前给予亚低温干预(28 ℃～30 ℃),(照射+亚低温)组照射后给予亚低温干预,动态观察各组小鼠体温、体重、外周血白细胞,照后28天解剖观察脏器与骨髓恢复情况。结果与单纯照射组相比,(亚低温+照射)组外周血白细胞数恢复时间提前1周,胸腺重量和系数增大,且差异显著;(照射+亚低温)组外周血白细胞数恢复时间提前4天。结论亚低温对6 Gy单次全身照射小鼠有一定的辐射损伤保护作用。

关键词: 亚低温, 急性照射, 辐射防护, 小鼠

Abstract: This paper is to investigate the effect of mild hypothermia on acute radiation syndrome in mice. Forty male BALB/c mice were randomly are divided into 4 groups. The mice were exposed to gamma ray at6.0 Gy,0.92 Gy/min, the mice in mild hypothermia+radiation group were receivedmild hypothermia treatment before irradiation and radiation+mild hypothermia group after irradiation. The descend range of pripheral blood leukocyte number in mild hypothermia+radiation group was 1 week in advance to restore; Thymus weightand coefficient increased, the ratio of PCE/(PCE+NCE) was lower than radiation group.The descend range of pripheral blood leukocyte number in radiation+mild hypothermia group was lower than radiation group on the first day after irradiation, and 4 days in advance to restore. The descend range of pripheral blood leukocyte number in mice treated by mild hypothermia either before or after irradiationdecreased lower in early time after irradiation and recovery earlier, Mild hypothermia had some protective effect on mice radiated at 6 Gy.

Key words: Mild hypothermia, Acute irradiation, BALB/c mice

中图分类号:

R818

李曙芳, 岳娟, 黄立群, 王永丽, 安全, 李幼忱, 周晋源. 亚低温对急性辐射损伤小鼠保护效果[J]. 辐射防护通讯, 2014, 34(3): 12-15.

Li Shufang, Yue Juan, Huang Liqun, Wang Yongli, An Quan, Li Youchen, Zhou Jinyuan. Effects of Mild Hypothermia on Acute Radiation Syndrome in Mice[J]. RADIATION PROTECTION BULLETIN, 2014, 34(3): 12-15.

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