辐射敏感基因检测作为生物剂量计研究动态

辐射防护通讯 ›› 2024, Vol. 44 ›› Issue (4): 21-31.

辐射敏感基因检测作为生物剂量计研究动态

陈钰婷^1,2, 杨学琴², 王革非¹

1.汕头大学医学院,广东汕头 515041;
2.深圳市职业病防治院,广东深圳 518020

收稿日期:2023-11-02 出版日期:2024-08-20 发布日期:2024-08-20
通讯作者: 王革非。E-mail:gefeiwang@stu.edu.cn
作者简介:陈钰婷(1990—),女,汕头大学在读硕士研究生,深圳市职业病防治院主管技师。E-mail:pony-nico@163.com
基金资助:
广东省医学科学技术研究基金(A2022230),放射卫生与放射病防治学科深圳市公共卫生重点专科 (SZXK068)。

Research trends of radiation sensitive gene detection used in biodosimetry

CHEN Yuting^1,2, YANG Xueqin², WANG Gefei¹

1. College of Medicine, Shantou University, Guangdong Shantou 515041;
2. Shenzhen Prevention and Treatment Center for Occupational Diseases, Guangdong Shenzhen 518020

Received:2023-11-02 Online:2024-08-20 Published:2024-08-20

摘要/Abstract

摘要： 采用 Web of Science核心合集数据库和中国知网数据库(CNKI)获得文献数据,运用文献计量学方法和CiteSpace(6.2.R4)、VOSviewer(版本号1.6.19)软件,以辐射敏感基因检测作为生物剂量计的研究主题在文献、作者、机构、期刊等方面进行分析。WOS数据库结果显示,2000—2023年,在辐射敏感基因检测作为生物剂量计研究主题的文献总量从3篇增长到297篇;美国是这个领域中研究比较活跃的国家,中国发文量排世界第7;Radiation Research,International Journal of Radiation Biology,Scientific Reports,Health Physics等是该研究主题的重要学术期刊同时也有较高的共被引频次;关键词聚类反映出该领域主要研究方向为DNA损伤-修复、细胞凋亡、p53信号通路、体内-体外试验、生物剂量计模型。共被引文献显示基因FDXR作为生物剂量计的研究是最近引用量最多的文献,也是该领域研究热点。CNKI数据库结果分析显示单个基因(MDM2、GADD45、XPC、FDXR、HPRT)剂量-效应关系研究是国内该领域主要研究方向。同时提示基因集群检查为基因检测作为生物剂量计未来研究方向。

关键词: 辐射敏感基因, 生物剂量计, 文献计量分析

Abstract: Using visual bibliometric analysis software CiteSpace (6.2.R4) and VOSviewer (version 1.6.19), the application and development of radiation sensitive gene detection in biodosimetry are summarized. Articles and reviews related to this field published between 2000 and 2023 were selected from Web of Science Core Collection and CNKI to analyze authors, institutions, journals, references and keywords in this field. The results of WOS database showed that from 2000 to 2023, the total of papers on radiation sensitive gene detection as a biodosimetry increased from 3 to 297. The United States topped the list in this field and China ranked the seventh. Radiation Research, International Journal of Radiation Biology, Scientific Reports, Health Physics were the most important journals in this field also had high co-citation frequency. Keyword cluster analysis showed that research focused on the damage-repair of DNA, apoptosis, p53 signaling pathway, in vivo-in vitro tests, and biodosimetry model systems. The co-cited references analysis showed that the application of FDXR gene detection as a biodosimetry have become the hotspot of this field. The CNKI database analysis showed that the dose-response relationship of genes (MDM2, GADD45, XPC, FDXR, HPRT) were main direction of studying in this field in China. At the same time, it is suggested that gene cluster examination is the future research direction of gene detection as biodosimetry.

Key words: radiation sensitive gene, biodosimetry, bibliometric

中图分类号:

Q691;TL818⁺.5

陈钰婷, 杨学琴, 王革非. 辐射敏感基因检测作为生物剂量计研究动态[J]. 辐射防护通讯, 2024, 44(4): 21-31.

CHEN Yuting, YANG Xueqin, WANG Gefei. Research trends of radiation sensitive gene detection used in biodosimetry[J]. RADIATION PROTECTION BULLETIN, 2024, 44(4): 21-31.

参考文献

[1] 全国科学技术名词审定委员会. 放射医学与防护名词[M].北京:科学出版社,2014.
[2] Coleman C N, Koerner J F. Biodosimetry: Medicine, science, and systems to support the medical decision-maker following a large scale nuclear or radiation incident[J]. Radiation Protection Dosimetry, 2016, 172(1/3): 38-46.
[3] Ko S, Chung H H, Cho S B, et al. Occupational radiation exposure and its health effects on interventional medical workers: Study protocol for a prospective cohort study[J]. BMJ Open, 2017, 7(12): e018333.
[4] Hoffmann W, Schmitz-Feuerhake I. How radiation-specific is the dicentric assay?[J]. Journal of Exposure Science & Environmental Epidemiology, 1999, 9(2): 113-133.
[5] Ghandhi S A, Shuryak I, Morton S R, et al. New approaches for quantitative reconstruction of radiation dose in human blood cells[J]. Scientific Reports, 2019, 9(1): 18441.
[6] Vinnikov V A, Belyakov O. Radiation exposure biomarkers in the practice of medical radiology: cooperative research and the role of the International Atomic Energy Agency (IAEA) biodosimetry/radiobiology laboratory[J]. Health Physics, 2020, 119(1): 83-94.
[7] Amundson S A. Transcriptomics for radiation biodosimetry: progress and challenges[J]. International Journal of Radiation Biology, 2023, 99(6): 925-933.
[8] Synnestvedt M B, Chen C, Holmes J H. CiteSpace II: Visualization and knowledge discovery in bibliographic databases[J]. AMIA Annual Symposium Proceedings, 2005, 2005: 724-728.
[9] van Eck N J, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping[J]. Scientometrics, 2010, 84(2): 523-538.
[10] 潘玮, 郑鹏, 黄锦泉, 等. 基于数据清洗“DEAN”流程的健康信息领域研究热点探测[J]. 现代情报, 2018, 38(10): 73-77.
[11] Ainsbury E A, Bakhanova E, Barquinero J F, et al. Review of retrospective dosimetry techniques for external ionising radiation exposures[J]. Radiation Protection Dosimetry, 2011, 147(4): 573-592.
[12] Cruz-Garcia L, O′Brien G, Sipos B, et al. in vivo validation of alternative FDXR transcripts in human blood in response to ionizing radiation[J]. International Journal of Molecular Sciences, 2020, 21(21): 7851.
[13] Port M, Majewski M, Herodin F, et al. Validating baboon ex vivo and in vivo Radiation-related gene expression with corresponding human data[J]. Radiation Research, 2018, 189(4): 389-398.
[14] O′Brien G, Cruz-Garcia L, Majewski M, et al. FDXR is a biomarker of radiation exposure in vivo[J]. Scientific Reports, 2018, 8(1): 684.
[15] Amundson S A, Do K T, Fornace A J Jr. Induction of stress genes by low doses of gamma rays[J]. Radiation Research, 1999, 152(3): 225-231.
[16] Amundson S A, Bittner M, Chen Y, et al. Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses[J]. Oncogene, 1999, 18(24): 3666-3672.
[17] Amundson S A, Do K T, Vinikoor L C, et al. Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute anticancer drug screen[J]. Cancer Research, 2008, 68(2): 415-424.
[18] Amundson S A, Grace M B, McLeland C B, et al. Human in vivo radiation-induced biomarkers: Gene expression changes in radiotherapy patients[J]. Cancer Research, 2004, 64(18): 6368-6371.
[19] 王成, 龙爽, 郝玉徽, 等. 美军武装部队放射生物学研究所的教育训练模式及其启示[J]. 华南国防医学杂志, 2019, 33(10): 717-719.