60Co γ射线8.0 Gy剂量诱导小鼠十二指肠恢复期损伤

辐射防护通讯 ›› 2016, Vol. 36 ›› Issue (3): 38-41.

⁶⁰Co γ射线8.0 Gy剂量诱导小鼠十二指肠恢复期损伤

任越, 董娟聪, 张忠新, 原雅艺, 王超, 左雅慧, 李幼忱

中国辐射防护研究院, 太原, 030006

收稿日期:2016-05-10 出版日期:2016-06-20 发布日期:2021-11-19
作者简介:任越(1989- ),男,2012年毕业于吉林大学放射医学专业,学士; 2015年毕业于中国辐射防护研究院放射医学专业,硕士; 研究实习员。

The Duodenum Injury of Mice in Recovery Phase Induced by 8.0 Gy γ-Irradiation of ⁶⁰Co

Ren Yue, Dong Juancong, Zhang Zhongxin, Yuan Yayi, Wang Chao, Zuo Yahui, Li Youchen

China Institute for Radiation Protection, Taiyuan, 030006

Received:2016-05-10 Online:2016-06-20 Published:2021-11-19

摘要/Abstract

摘要： 采用⁶⁰Co γ射线对小鼠腹腔进行一次性照射,照射剂量为8.0 Gy,在照射后第15 d的恢复期,观察小鼠十二指肠的病理变化,分析BCL-2和TGF-β蛋白质表达水平。结果表明:(1) 与对照组相比,照射组十二指肠病理出现绒毛萎缩、变短或脱落,严重者可见肠粘膜上皮广泛性坏死剥脱;(2) 照射组BCL-2蛋白质表达水平下降,TGF-β蛋白质表达水平升高。结果说明,该照射方法下恢复期时放射性肠损伤仍然存在。

关键词: 放射性十二指肠炎, 小鼠, 恢复期

Abstract: Gamma irradiation was given one-timewith a dose of 8.0 Gy from ⁶⁰Co in mice peritoneal. On the 15th day after irradiation, the duodenum were taken out to observe the pathological changesand analyze the expression level of BCL-2 and TGF-β. The results show that:1)Compared with controls, the duodenum pathology of radiation group appear villiartophy, shorter or fall-off. For severe cases, intestinal mucosa epithelium extensive necrosis and desquamation is observed. 2) BCL-2 expression level drops, and TGF-β expression level rises, in radiation group. The experiment provesthat under the radiation situation, the duodenum radiation injury still exists in recovery phase.

Key words: Radioactive Duodenitis, Mice, Recovery phase

中图分类号:

TL818

任越, 董娟聪, 张忠新, 原雅艺, 王超, 左雅慧, 李幼忱. ⁶⁰Co γ射线8.0 Gy剂量诱导小鼠十二指肠恢复期损伤[J]. 辐射防护通讯, 2016, 36(3): 38-41.

Ren Yue, Dong Juancong, Zhang Zhongxin, Yuan Yayi, Wang Chao, Zuo Yahui, Li Youchen. The Duodenum Injury of Mice in Recovery Phase Induced by 8.0 Gy γ-Irradiation of ⁶⁰Co[J]. RADIATION PROTECTION BULLETIN, 2016, 36(3): 38-41.

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⁶⁰Co γ射线8.0 Gy剂量诱导小鼠十二指肠恢复期损伤

The Duodenum Injury of Mice in Recovery Phase Induced by 8.0 Gy γ-Irradiation of ⁶⁰Co

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