干细胞规模化扩增技术在核应急医学救援中的应用策略

辐射防护通讯 ›› 2026, Vol. 46 ›› Issue (2): 39-43.

干细胞规模化扩增技术在核应急医学救援中的应用策略

杨超, 刘明浩, 朱磊, 白帆, 陈双景, 郭姗姗, 王佳楠

火箭军特色医学中心,北京 100088

收稿日期:2025-11-01 出版日期:2026-04-20 发布日期:2026-05-07
通讯作者: 王佳楠。E-mail:wangjianan_wjn@163.com
作者简介:杨超(1982—),女,2010年毕业于军事医学科学院病理学与病理生理学专业,获博士学位,主治医师,主要从事辐射损伤院内救治与核应急医学救援工作。E-mail:yangchao0120@126.com

Application strategy of stem cell scale expansion technology in nuclear emergencymedical rescue

YANG Chao, LIU Minghao, ZHU Lei, BAI Fan, CHEN Shuangjing, GUO Shanshan, WANG Jianan

PLA Rocket Force Characteristic Medical Center, Beijing 100088

Received:2025-11-01 Online:2026-04-20 Published:2026-05-07

摘要/Abstract

摘要： 针对辐射暴露导致的多器官损伤和造血功能衰竭,传统对症支持治疗手段有限,干细胞规模化扩增技术具有在核应急医学救援中实现快速、批量治疗的潜力,可作为传统对症支持治疗的重要补充,为解决辐射损伤人员的救治难题提供了新思路。本文拟探讨干细胞规模化扩增技术在核应急医学救援中的应用策略。

关键词: 核应急医学救援, 干细胞, 规模化扩增技术, 应用策略

Abstract: With the widespread global application of nuclear energy and rising geopolitical risks, the potential threat of nuclear and radiological emergencies (NRE) persists. Nuclear radiation exposure can lead to multi-organ and multi-system damage, and traditional symptomatic supportive care and treatment are limited. Stem cells provide revolutionary therapeutic potential for nuclear emergency medical rescue by virtue of their multiple biological functions such as tissue repair, immune regulation and hematopoietic reconstruction. This paper intends to explore the application strategy of stem cell scale expansion technology in nuclear emergency medical rescue.

Key words: nuclear emergency medical rescue, stem cells, large-scale amplification technology, application strategy

中图分类号:

R818

杨超, 刘明浩, 朱磊, 白帆, 陈双景, 郭姗姗, 王佳楠. 干细胞规模化扩增技术在核应急医学救援中的应用策略[J]. 辐射防护通讯, 2026, 46(2): 39-43.

YANG Chao, LIU Minghao, ZHU Lei, BAI Fan, CHEN Shuangjing, GUO Shanshan, WANG Jianan. Application strategy of stem cell scale expansion technology in nuclear emergencymedical rescue[J]. RADIATION PROTECTION BULLETIN, 2026, 46(2): 39-43.

参考文献

[1] Streffer C, Hande M P. Effects of ionizing radiation exposure in offspring and next generations[J]. International Journal of Radiation Biology, 2024, 100(9): 1 237-1 239.
[2] Davies L C, Biard L, García-Olmo D, et al. Defining minimal criteria for peer-reviewed reporting of mesenchymal stromal cell clinical trials for autoimmune diseases[J]. Cytotherapy, 2025, 27(11): 1 326-1 337.
[3] Lee O J, Keating A. Mesenchymal stromal cells: an update[J]. Current Opinion in Hematology, 2025, 32(5): 270-278.
[4] Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement[J]. Cytotherapy, 2006, 8(4): 315-317.
[5] XU Hui, ZHANG Jinwang, ZHANG Hexiao, et al. The inhibitory impact of various total body irradiation doses on the hematopoietic system of mice[J]. Blood science, 2024, 7(1): e00214.
[6] Lmamura M, Shigematsu A. Perspectives on the use of a medium-dose etoposide, cyclophosphamide, and total body irradiation conditioning regimen in allogeneic hematopoietic stem cell transplantation: the Japanese experience from 1993 to present[J]. Journal of Clinical Medicine, 2019, 8(5): 569.
[7] GAO Dandan, ZHANG Heng, SUN Wanjun, et al. Radiation-induced intestinal injury: molecular mechanisms and therapeutic status[J]. DNA and Cell Biology, 2024, 43(11): 537-548.
[8] LUO Yujun, WANG Beibei, LIU Jianhua, et al. Ginsenoside RG1 enhances the paracrine effects of bone marrow-derived mesenchymal stem cells on radiation induced intestinal injury[J]. Aging, 2020, 13(1): 1 132-1 152.
[9] YANG Leilei, FANG Chengfeng, SONG Caifang, et al. Mesenchymal stem cell-derived exosomes are effective for radiation enteritis and essential for the proliferation and differentiation of Lgr5⁺ intestinal epithelial stem cells by regulating Mir-195/Akt/β-Catenin pathway[J]. Tissue Engineering and Regenerative Medicine, 2023, 20(5): 739-751.
[10] Arroyo-Hernández M, Maldonado F, Lozano-Ruiz F, et al. Radiation-induced lung injury: current evidence[J]. BMC Pulmonary Medicine, 2021, 21(1): 9.
[11] WANG Hongyu, WANG Jinbao, YANG Gaosheng, et al. Human umbilical cord mesenchymal stem cell-derived exosomes mitigate acute radiation-induced intestinal oxidative damage via the Nrf2/HO-1/NQO1 signaling pathway[J]. PLoS One, 2025, 20(6): e0324238.